氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效观察

The Clinical Effect Observation of Clopidogrel Combination with Aspirin in Treatment of Unstable Angina Pectoris

目的观察氯吡格雷与阿司匹林联合应用治疗不稳定型心绞痛(UAP)的临床疗效及安全性。方法将我院已确诊的86例UAP患者随机分成观察组和对照组,各43例,在常规治疗后,对照组患者单用阿司匹林,观察组在对照组治疗的基础上联合服用氯吡格雷。随访1个月,比较两组患者的心绞痛改善效果、心电图改善效果及不良反应。结果心绞痛改善效果:治疗1个月后,观察组总有效率为88.4%,对照组总有效率为60.5%,两组疗效比较,差异有统计学意义(P<0.05);心电图疗效:观察组总有效率为93.0%,对照组为58.1%,两组疗效比较,差异有统计学意义(P<0.05);两组治疗期间均未出现严重不良反应。结论抗血小板药物氯吡格雷联合阿司匹林可明显改善UAP患者的症状,优于单独应用阿司匹林,且安全性高,值得在临床上推广。

Objective To observe the therapeutic effect and safety of clopidogrel combined with aspirin in treatment of unstable angina pectoris.Methods Our hospital diagnosed 86 cases of UAP patients were randomly divided into observation group and control group,43 cases each,in the conventional treatment,patients in the control group with aspirin alone,the observation group were combined with clopidogrel therapy based on the treatment in control group.Follow-up of 1 months,compared two groups of patients with angina pectoris,ECG improvement effect to improve the efficacy and adverse reaction.Results The angina improvement effect：after 1 months of treatment,the total effective rate of the observation group was 88.4%,the total efficiency of control group was 60.5%,compared with two groups of curative effect,the difference was statistically significant（P0.05）;curative effect of ECG：the observation group total effectiveness was 93.0%,the control group was 58.1%,compared with two groups of curative effect,the difference was statistically significant（P0.05）;there was no serious adverse reaction occurred during the treatment in the two groups.Conclusion Antiplatelet therapy with clopidogrel and aspirin can significantly improve the symptoms of the UAP patients,is superior to aspirin alone,and high safety,which is worthy of clinical application.