阻塞性睡眠呼吸暂停综合征致缺血性脑卒中相关炎症因子的研究

Research on Inflammatory Cytokines in Ischemic Stroke Associated with Obstructive Sleep Apnea Syndrome

阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)是一种临床常见睡眠呼吸紊乱疾病。研究证实,OSAS作为缺血性脑卒中的独立危险因素,由于夜间低氧血症和高碳酸血症进而通过多种机制导致缺血性脑卒中的发生、发展,炎症反应就是最重要的机制之一。OSAS患者体内较高水平的炎症因子参与了炎症反应过程,增加了卒中的严重性及治疗的复杂性。

Obstructive sleep apnea syndrome（OSAS）is a common sleep-related breathing disorders in clinical diseases.According to study,OSAS is an independent risk factor for ischemic stroke,since hypoxemia and hypercapnic symptoms recurring at night through a variety of mechanisms leading to the occurrence and development of ischemic stroke.Inflammatory response is one of the most important mechanisms in ischemic stroke associated with obstructive sleep apnea syndrome.High level inflammatory factors in OSAS patients are involved in inflammatory response.