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血塞通冻干粉对急性脑梗死患者血小板活化标志物的影响 被引量:6

Effects of Xuesaitong Lyophilized Powder on Biomarkers Relative to Platelet Activation in Patients with Acute Cerebral Infarction
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摘要 目的探讨血塞通冻干粉对急性脑梗死患者血小板活化标志物的影响。方法将60例急性脑梗死患者随机分为两组,对照组给予肠溶阿司匹林、依达拉奉静脉滴注及丁苯酞作为基础治疗;治疗组在对照组治疗的基础上给予血塞通冻干粉静脉滴注。应用流式细胞仪分别检测治疗前后血小板黏附、释放、聚集功能的变化,同时进行凝血功能、超敏C反应蛋白(hs-CRP)、血常规、血生化检查。结果应用血塞通冻干粉后治疗组患者的CD62p、血小板膜糖蛋白Ⅱb/Ⅲa(PAC-1)、血小板-单核细胞聚集体(PMA)较对照组下降,差异有统计学意义(P<0.05);两组CD42b及CD61比较,差异无统计学意义(P>0.05)。结论血塞通冻干粉能抑制脑梗死患者血小板的激活和PMA的形成,有明确的抗血小板作用。 Objective To discuss the effect of Xuesaitong lyophilized powder to antiplatelet in patients with acute cerebral infarcion.Methods 60 cases of acute cerebral infarction were randomly divided into two groups.The control group was given aspirin,edaravone intravenous infusion and butylphthalide as basic treatment;Treatment group was treated with Xuesaitong lyophilized powder for intravenous injection based on the treatment in control group.Before and after treatment were detected by platelet adhesion,aggregation,release the changes by flow cytometry,and coagulation function,high sensitive C reactive protein(hs-CRP),blood routine,blood biochemical examination.Results The treatment group were treated with Xuesaitong lyophilized powder of CD62p,platelet glycoprotein Ⅱb/ Ⅲa(PAC-1),platelet monocyte aggregates(PMA) decreased significantly compared with the control group,the difference was statistically significant(P0.05);compared with two groups of CD42b and CD61,there was no significant difference(P0.05).Conclusion Xuesaitong lyophilized powder can inhibit the formation of platelet in patients with cerebral infarction and the activation of PMA,there are definite anti-platelet action.
出处 《实用心脑肺血管病杂志》 2013年第4期63-65,共3页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 血塞通 脑梗死 血小板活化因子 Xuesaitong Brain infarction Platelet activating factors
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