1Grohmann R.Adverse psychic reactions to psychotropic drugs a report from the AMUP study[J].Pharmacopsychiatry,1993,26: 84～ 93
2Cole JO.Tricyclic use in hte cognitively impaired elderly[J].J Clin psychiatry, 1993,44:14～ 19.
3Hindmarch I.Antidepressants:The im plications of the cognitive and psy chomotor effects in the elderly[J].Int Clin Psychopharm,1990,5:57～ 60
4Knegtering H,Eijick M.Effects of an tidepressants on cognitive functioning of eldeerly patients:A veview[J].Drug aG ING ,1994,5:192～ 99
5Amado BI,Gougoulis N,Poirier LMF,et al.Effects of antidepressants on cognitive functions[J].Neurosci Biobehav Rev, 1995,19:479～ 493
6Sternberg H.The serotonin syndrome[J]. Am J Psychiatry,1991,148:F705～ 713
7Finelli PF,Drug induced Cruetzfeldt-Jakob like syndrome[J].J Psychiatr Neurosci,1992,17:103～ 125
8King DJ.The effect of neruoleptics on cognitive and psychomotor function[J].Br J Psychiatry ,1990,157:799～ 811
9Goldberg TE,Weinberger DR.Effects of neuroleptic medications on the cognition of patients with schizophrenia:A review of recent studies[J].Clin Psychiatry, 1996,57:62～ 65
10Barbee JG.Memory,benzodiazepines and anxiety:Integration of theoretical and clinical perspectives[J].J Clin Psychiatry， 1993,54(suppl 10):86～ 97
3Selkoe DJ.Alzheimer's disease: genes, proteins, and therapy.Physiol Rev 2001;81(2):741-66
4Kumar VB, Farr SA, Flood JF, et al.Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice.Peptides 2000; 21(12):1769-75
5Kojro E, Gimpl G, Lammich S, et al.Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10.Proc Natl Acad Sci USA 2001;98(10):5815-20
6Yang LB,Lindholm K,Yan R, et al.Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.Nat Med 2003;9(1):3-4
7Vassar R, Bennett BD, Babu-Khan S, et al.Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.Science 1999;286(5440):735-41
9Cai H, Wang Y, McCarthy D,et al.BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.Nat Neurosci 2001;4(3):233-4
10Luo Y, Bolon B, Kahn S, et al.Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.Nat Neurosci 2001;4(3):231-2
