西酞普兰治疗脑卒中后抑郁伴焦虑效果观察

Effect Observation of Citalopram in Treatment of Post-stroke Depression and Anxiety

目的观察西酞普兰治疗脑卒中后抑郁伴焦虑的效果。方法将北京军区总医院263临床部神经内科2010年1月—2012年1月收治的200例脑卒中后抑郁伴焦虑患者随机分为研究组和对照组,每组100例。均给予常规治疗和积极心理干预,研究组同时给予西酞普兰20 mg口服、1/d。比较两组治疗前后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分和疗效,同时观察不良反应。结果两组治疗后1、2、4、6周HAMD、HAMA评分均显著低于治疗前(P<0.01)。研究组HAMD、HAMA评分明显低于对照组(P<0.01),总有效率亦高于对照组(P<0.01)。两组均未发现明显不良反应。结论西酞普兰治疗脑卒中后抑郁伴焦虑症状效果好,且较安全,可提高患者的生活质量。

Objective To observe effect of Citalopram in treatment of post-stroke depression and anxiety.Methods A total of 200 patients with post-stroke depression and anxiety in our department during January 2010 and January 2012 were randomly divided into therapy group（n = 100） and control group（n = 100）.Based on conventional therapy,the control group was given positive psychological intervention,while therapy group was given Citalopram treatment（20 mg oral,1 time/d） and positive psychological intervention.Scores and effects of Hamilton depression scale（HAMD） and Hamilton anxiety scale（HAMA） in the two groups before and after treatment were compared,and adverse reactions were observed.Results Scores of HAMD and HAMA at 1,2,4 and 6 weeks after treatment were significantly lower than those before treatment in two groups（P 0.01）.Scores of HAMD and HAMA in therapy group were significantly lower than those in control group（P 0.01）,total effective rate in therapy group was also higher than that in control group（P 0.01）.There was no adverse reaction in two groups.Conclusion The method of Citalopram in treatment of post-stroke depression and anxiety is effective and safe,which can improve the patients＇ quality of life.