儿童慢性丙型肝炎应用干扰素联合利巴韦林治疗中发生惊厥的临床分析

Clinical Analysis on Convulsions Seizures Induced by Interferon Combined with Ribavirin in Treatment of Children with Chronic Hepatitis C

目的探讨儿童慢性丙型肝炎(CHC)应用干扰素联合利巴韦林抗病毒治疗中发生惊厥的临床特点及应对策略。方法解放军302医院2002年1月—2012年1月收治489例1～6岁CHC住院或门诊患儿,观察统计应用普通干扰素或聚乙二醇干扰素α联合利巴韦林抗丙型肝炎病毒治疗过程中发生的惊厥病例,分析惊厥的诱因、临床表现、处理方法及预后。结果 489例儿童CHC中发生惊厥17例,均为干扰素所致单纯性热性惊厥,惊厥持续时间短,恢复较快,未引发癫痫等不良后果,不影响干扰素的继续使用。结论正确认识儿童CHC干扰素联合利巴韦林治疗中发生惊厥的临床特点,合理应对,对保证抗病毒治疗的成功率及安全性具有重要意义。

Objective To explore the clinical characteristics and coping strategies of convulsions seizures induced by Interferon combined with Ribavirin in treatment of children with chronic hepatitis C.Methods Clinical characteristics of convulsions seizures induced by Interferon（or Peginterferon） combined with Ribavirin in HCV therapy in clinic and inpatient 489 children with chronic hepatitis C at the age of 1-6 years during January 2002 and January 2012 in 302 hospital of PLA were observed,and precipitating factors,clinical manifestations,treatment methods and prognosis of seizures were analyzed.Results Among 489 children,17 patients occurred retinitis simplex febrile convulsions caused by Interferon,and seizures with short duration and rapid recovery had no adverse consequence such as Epilepsy,which had not affect on the continual use of interferon.Conclusion A correct understanding of clinical characteristics and effective actions of convulsions seizures induced by Interferon combined with Ribavirin in treatment of children with chronic hepatitis C might be of significance in safety and efficacy of antivirus therapy.