摘要
目的研制黄芩苷固体分散体,并对其进行考察。方法以PEG6000为载体,用溶剂法、熔融法、溶剂-熔融法、研磨法制备黄芩苷固体分散体,并通过紫外、红外、溶解度、溶出度的考察比较不同药物与载体的比例对固体分散体的影响。结果溶剂法即共沉淀法,药物与PEG6000的比例为1:8时的固体分散体最优。结论制备方法和药物与载体的比例都会影响黄芩苷-PEG6000固体分散体的质量。
Objective : To prepare and investigate baicalin solid dispersion. Methods: Using PEG6000 as cartier, baicalin solid dispersion was prepared by solvent, melting, solvent-melting, grinding methods. The influence on solid dispersion of different proportion was studied by UV, IR, solubility and dissolution rate. Results: The solid dispersions of solvent method and the ratio of the drug and PEG6000 1:8 is the best. Conclusion: The quality of solid dispersion was affected by the preparation method and the ratio.
出处
《井冈山大学学报(自然科学版)》
2013年第2期89-93,共5页
Journal of Jinggangshan University (Natural Science)
关键词
黄芩苷
固体分散体
溶出度
溶剂法
baicalin
solid dispersion
dissolution rate
solvent method