18例精神障碍伴发阻塞性睡眠呼吸暂停综合征患者的多导睡眠图研究

Polysomnographic studies in 18 mental patients accompanying obstructive sleep apnea syndrome (OSAS)

目的 探讨精神障碍伴发阻塞性睡眠呼吸暂停综合征 (OSAS)患者的临床特点及睡眠生理改变。方法 对 42 0例精神障碍患者进行多导睡眠图 (PSG)检测。将检出的 18例 OSAS与 18例正常对照进行比较。 结果 1病例组打鼾、睡眠憋醒、白天嗜睡、记忆减退症状较对照组明显增多 (P <0 .0 1)。 2与对照组比较 ,病例组醒觉次数、觉醒时间、 期睡眠、鼾声指数及呼吸紊乱指数增高 , 、 期深睡眠减少 ,夜间最低血氧饱和度及韦氏记忆量表分减少 ,最长呼吸及平均呼吸暂停时间延长 (P均 <0 .0 1)。结论 夜间睡眠结构紊乱、低氧血症可能是 OSAS伴发精神障碍的病理基础。

Objective To explore the clinical characters and physiologic changes of sleep in mental patients accompanying OSAS. Methods All night polysomnographic recordings were performed in 420 mental patients,and 18 OSAS patients were compared with 18 normal controls matched. Results ①The incidences of snoring, daytime lethargy, choking during sleep and poor memory in patient group were higher than that in control group(P<0.01). ②Compared with control group , awake time, number of arousals, stageⅠsleep, apnea plus hypopnta index(AHI), snoring index in patient group increased highly(P<0 01); slow wave sleep, lowest SaO 2 score and Wechsler Memory Scale score in patient group decreased lowly(P<0 01). Maximum apnea time and mean apnea time were longer in patient group than that in control group. Conclusion Nocturnal disorders of sleep structure and hypoxenia may be a pathological foundation in mental patients accompanying OSAS.