4-氯代异喹啉类衍生物的合成与表征

Synthesis and Characterization of 4-Chloroisoquinolines

在PdCl2/CuCl2/Cy2NH2Cl的催化体系中,邻炔基苄基叠氮可以顺利地发生亲电环化反应选择性合成3-取代-4-氯代异喹啉,产率38%～84%,其结构经1H NMR,13CNMR和GC-MS表征.该方法反应条件温和、操作简单,并且在产物骨架中引入卤原子,为新官能团的引入提供了途径.

In the presence of PdCl2/CuCl2/Cy2NH2Cl, a variety of 2-alkynyl benzyl azides smoothly underwent the electronic cyelization to afford the corresponding 3-substituted 4-chloroisoquinolines in 38% -84% yields. The structures were confirmed by 1H NMR, 13C NMR and GC-MS. This method had many merits such as simple operation and mild reaction condition. Importantly, a halide was introduced into the products which makes the methodology more attractive for organic synthesis.