摘要
目的探讨不同类型珠蛋白生成障碍性贫血红细胞参数的分布特点。方法对经基因确诊的224例珠蛋白生成障碍性贫血患者和100例体检健康人群的标本,用美国雅培CD3700全自动血细胞分析仪测定红细胞参数,然后进行统计学处理分析。结果标准型α珠蛋白生成障碍性贫血、静止型α珠蛋白生成障碍性贫血、H病、轻型β珠蛋白生成障碍性贫血、HbE的红细胞平均体积(MCV)、红细胞平均血红蛋白含量(MCH)、红细胞平均血红蛋白浓度(MCHC)与健康对照组比较差异均有统计学意义(P<0.05)。不同基因类型珠蛋白生成障碍性贫血其红细胞参数有一定的分布区间。结论珠蛋白生成障碍性贫血患者红细胞参数有其独特的血液学特征,对诊断珠蛋白生成障碍性贫血具有一定的临床价值,为进一步基因诊断提供了必要的依据。
Objective To investigate the distribution characters of RBC indexes of different thalassemia geno- types. Methods The blood samples were collected from 224 thalasssemia patients and 100 healthy people,which were diagnosed by gene chip and Gap-PCR. All samples were analyzed by CD3700 for the erythrocyte indexes. Then the data were analyzed statistically. Results Compared to the normal control group,there was statistical significance in the decrease of MCV, MCH and MCHC in thalassemia,including α-thalassemia trait, silent α-thalassemia, HbH,mild β-thalassemia and HbE. RBC parameters of different thalassemia genotypes had some distribution interval. Conelu- sion There is distinct character of hematological indexes of RBC in thalasssemia patients,which has some clinical value for thalasssemia diagnosis and provides necessary evidence for further genetic diagnosis.
出处
《检验医学与临床》
CAS
2013年第6期647-648,653,共3页
Laboratory Medicine and Clinic
基金
广东省社会发展计划(2011B031800329)
广东省医学科研基金(A2011758
B2010348
A2012837)