血浆同型半胱氨酸与D-二聚体测定在老年高血压及高血压并脑梗死的临床应用

Clinical application of plasma homocysteine and D-dimer detection in elderly hypertension and hypertension complicating cerebral infarction

目的探讨血浆同型半胱氨酸(Hcy)与D-二聚体在老年高血压和高血压并脑梗死患者中的变化及其临床意义。方法设定老年高血压、老年高血压并脑梗死和健康对照3组,Hcy在贝克曼DXC-600全自动生化分析仪上应用循环酶法原理检测;D-二聚体在美国Instrumentation Laboratory公司生产的ACL-FUTURA全自动血凝仪上用比浊法原理检测。对比3组的Hcy、D-二聚体水平。结果老年高血压组和高血压伴脑梗死组血浆Hcy和D-二聚体浓度与健康对照组比较差异有统计学意义(P<0.05),且老年高血压组与高血压伴脑梗死组之间差异有统计学意义(P<0.01)。结论联合检测血浆Hcy和D-二聚体水平对老年人高血压和因高血压致脑梗死的预防、诊疗具有重要的临床意义。

Objective To investigate the change of plasma homocysteine（Hey） and D-dimer in elderly hyper- tension and hypertension complicating cerebral infarction and their clinical significance. Methods The elderly hyper- tension group（43 elderly cases）, elderly hypertension complicating cerebral infarction group（86 cases） and the health- y control group were included in this study. The Hcy level was detected by the enzymatic cycling assay with the DXC- 600 fully automatic biochemical analyzer and D-dimer by nephelometry with the ACL-Futural fully automatic coagula- tion analyzer. Results The levels of Hcy and D-dimer in the hypertension and the hypertension complicating cerebral infarction groups were statistically different from that of the healthy control group（P〈0.05）. There was also statis- tical difference between the elderly hypertension and elderly hypertension complicating cerebral infarction groups（P 〈0.01）. Conclusion Combined detection of Hcy and D-dimer is of great significance in the prevention,diagnosis and therapy of elderly hypertension and hypertension-causing cerebral infarction.