糖尿病合并恶性肿瘤患者免疫球蛋白水平变化的意义

The changing significance of immunoglobulin levels in diabetic patients with malignant tumor

目的:通过比较糖尿病肿瘤组与糖尿病非肿瘤组间免疫球蛋白水平,了解在糖尿病合并肿瘤患者的免疫功能状态。方法:采用病例对照研究,将患者分为三组:糖尿病肿瘤组(MG组)、糖尿病非肿瘤组(NMG组)、对照组,用放射性免疫方法测定IgA、IgM、IgG水平,比较三组间指标差异。结果:糖尿病肿瘤组、糖尿病非肿瘤组患者IgM、IgA有升高,但肿瘤组更加明显,IgG在两组无变化。结论:糖尿病患者免疫功能紊乱,在合并肿瘤时更加明显,在HbA1C>11.1%时免疫功能状态明显紊乱,较血糖控制理想时紊乱更加明显。糖尿病血糖控制水平差,可能是其导致肿瘤的原因,其中免疫功能紊乱是其参与肿瘤形成的原因之一。

Objective：To understand the state of the immune function in diabetic patients with tumors by comparing the immunoglobulin levels between the diabetes malignancy group and the diabetes non-malignancy group.Methods：The patients were randomly divided into three groups,the diabetes malignancy group,the diabetes non-malignancy group and the control group.The contents of IgA,IgM and IgG were measured by radioimmunoassay method.The indicators among the three groups were compared.Results：The IgM and IgA contents in the diabetes non-malignancy group increased,but those in the diabetes malignancy group increased more apparently.IgG in both groups had no variation.Conclusion：The immune function disorders of the diabetic patients became more pronounced when combined with tumor.The disorder became more apparently especially when HbA1C〉11.1%.Bad blood sugar level in the diabetes patients may cause tumors,and immune dysfunction is one of the reasons for tumor formation.