灯盏花素与激素联合环磷酰胺治疗活动性狼疮性肾炎的疗效观察

Curative effect of breviscapine combined with glucocorticoid and cyclophosphamide in the treatment of active lupus nephritis

目的观察灯盏花素联合激素和环磷酰胺(CTX)治疗活动性狼疮性肾炎(LN)的临床疗效。方法将66例LN患者按随机原则分为两组各33例,对照组予常规激素及CTX治疗,治疗组在常规治疗基础上加灯盏花素治疗。所有患者随访6个月,观察并比较两组LN患者临床疗效及服药后毒副作用等指标。结果治疗6个月后,治疗组总的治疗有效率明显高于对照组,两组比较差异有统计学意义(P<0.05);治疗组患者尿蛋白及尿RBC下降程度、抗核抗体转阴率及C3恢复正常率显著优于对照组(P<0.05),与对照组比较其差异均具有统计学意义(P<0.05);治疗过程中,治疗组患者毒副作用的发生率低于对照组(P<0.05)。结论灯盏花素联合激素和环磷酰胺治疗活动性狼疮性肾炎不仅能提高疗效,还能显著降低西药的毒副作用。

Objective To observe the clinical efficacy of breviscapine combined with prednisone and cyclo-phosphamide （CTX） in treatment of active lupus nephritis （LN）. Methods Sixty-six patients of LN were randomly divided into two groups, with 33 patients in each group. Patients in the control group were given conventional thera-py of prednisone and cyclophosphamide （CTX）, while those in the study group were given breviscapine combined with prednisone and cyclophosphamide. The clinical efficacy and side effects were compared between the two groups. Results After 6 months of treatment, the total clinical efficacy of the study group was significantly higher than that of the control group （P〈0.05）. The decline degree of urinary protein and urinary RBC, antinuclear antibod-ies negative conversion ratio and recovery rate of C3 were found to be significantly better in the study group than the control group （P〈0.05）. The incidence of side effects was significantly lower grouping the study group （P〈0.05）. Conclusion Breviscapine combined with glucocorticoid and eyclophosphamide in treatment of active LN can not on-ly improve the efficacy, but also significantly reduce the toxic side effects.