亚剂量丙种球蛋白治疗特发性血小板减少性紫癜40例临床疗效观察

Effect of subclinical doses gamma globulinin in the treatment of children with ITP

目的探讨不同剂量丙种球蛋白对特发性血小板减少性紫癜患儿的治疗效果。方法随机将79例特发性血小板减少性紫癜患儿分为两组,标准剂量组(n=39)予大剂量丙种球蛋白治疗,亚剂量组(n=40)予亚剂量丙种球蛋白治疗,比较两组疗效。结果两组患儿治疗6d、9d、14d后血小板计数比较,差异无统计学意义(t=1.14、0.75、0.45,P>0.05)。两组患儿治疗14d后巨核细胞计数较治疗前明显减少(P<0.05),但两组患儿治疗后计数差异无统计学意义(P>0.05)。两组患儿平均出血消失时间差异无统计学意义(t=0.48,P>0.05)。结论亚剂量丙种球蛋白用于特发性血小板减少性紫癜患儿和标准剂量疗效相当,节省了医疗费用。

Objective To explore the effect of subclinical doses gamma globulinin in the treatment of children with ITP. Methods 79 children with ITP were divided into two groups randomly, while standard dose group received large dose gamma globulin and subclinical doses group received subclinical doses gamma globulin. Results After thera-py 6, 9, 14 days, platelet count of two groups have been compared, and there were no a significant difference be- tween them （t=1.14, 0.75, 0.45）. After therapy 14 days, megakaryocyte count of two groups was significantly re-duced （P〈0.05）, but there was no a signigicant difference between two groups. Average bleeding disappeared time have no a significant difference between two groups. Conclusion For children with ITP, subclinical doses gamma globulin has a similar effect as standard dose.