原发性高血压肾病患者血清胱抑素C和视黄醇结合蛋白检测的临床意义

Clinical significance of serum cystatin C and retinol binding proteinin in patients with primary hypertension nephropathy

目的探讨原发性高血压肾病患者血清胱抑素C(Cysc)和血清视黄醇结合蛋白(RBP)水平检测的临床意义。方法应用免疫比浊法对184例原发性高血压患者(正常蛋白尿组57例,微量蛋白尿组59例,大量蛋白尿组68例)血清Cysc、RBP以及尿液微量蛋白(MALB、IgG、TRFU、α1-MG、β2-MG)的水平进行检测,并与72例健康体检者(正常对照组)进行对比分析。结果微量蛋白尿组和大量蛋白尿组患者血清Cysc、RBP尿MALB、IgG、TRFU、α1-MG、β2-MG等各项微量蛋白水平显著高于正常对照组和正常蛋白尿组,差异有统计学意义(P<0.05)。原发性高血压肾病患者血清Cysc与血清RBP及各项尿MALB、IgG、TRFU、α1-MG、β2-MG等微量蛋白指标水平呈正相关(r=0.92、0.85、0.76、0.67、0.58、0.63,P<0.05)。结论血清Cysc与RBP及各项尿ALB、IgG、TRFU、α1-MG、β2-MG等微量蛋白含量随原发性高血压肾病的发生以及严重程度逐渐增高,可作为早期诊断和监测原发性高血压肾病敏感的指标。

Objective To explore the clinical significance of serum cystatin C（CYSC） and retinol binding proteinin（RBP） in patients with primary hypertension nephropathy.Methods Serum CYSC,RBP and urine microprotein levels（MALB,IgG,TRFU,α1-MG,β2-MG） were detected with immunoturbidimetry in 184 patieents（57 cases in the normal albuminuria group,59 cases in the microalbuminuria group and 68 cases in the macroalbuminuria group） with primary hypertension nephropathy,and compared with those of 72 healthy voluntes（the control group）.Results The levels of CYSC,RBP,MALB,IgG,TRFU,α1-MG and β2-MG in the microalbuminuria group and 68 macroalbuminuria group were significantly higher than those in the control group and the normal albuminuria group（P 0.05）.Serum CYSC had positive correlation with RBP,MALB,IgG,TRFU,α1-MG and β2-MG（r=0.92,0.85,0.76,0.67,0.58,0.63,P0.05） in the patients.Conclusion The levels of CYSC,RBP,M ALB,IgG,TRFU,α1-MG and β2-MG increase gradually with the primary hypertension nephropathy getting more severe.It could be used as a sensitive marker for early monitoring the development and progress of primary hypertension nephropathy.