妊娠期TORCH感染与不良结局相关性分析

Correlation between TORCH infection and adverse pregnancy outcome

目的探讨三亚地区妊娠期TORCH感染的现状及其与不良妊娠结局的关系,为进一步开展出生缺陷的预防和干预工作提供科学数据。方法采用酶联免疫吸附试验(ELISA)检测方法检查4046例孕妇血清中的TORCH-IgM抗体并对其进行追踪,随访孕妇的妊娠结局。结果 4046例受检孕妇中,失访198例,最终随访3848例。其中异常妊娠致流产326例、胎膜早破231例、胎死宫内5例。TORCH-IgM阳性孕妇46例,占1.20%。TORCH-IgM阳性的孕妇不良妊娠结局发生率为69.57%,明显高于TORCH-IgM阴性孕妇的13.94%(P<0.01)。结论妊娠期TORCH感染与自然流产、早产、胎死宫内等妊娠不良结局有关。

Objective To investigate the relationship between TORCH infection and adverse pregnancy outcome,and to provide data and recommendations for birth defects intervention.Methods TORCH-IgM antibody in the serum of 4 046 pregnant women was examined by ELISA.The women with positive result were followed up and the outcome of their pregnancy was collected.Results Of the 4 046 pregnant women,198 patients were lost in the follow-up,and 3 848 were followed up finally,including 326 cases of abortion,231 cases of premature rupture of membrane,5 cases of intrauterine death.TORCH-IgM was found positive in 46 patients（accounting for 1.20%）,of which 69.57% had adverse pregnancy outcome,significantly higher than 13.94% in the TORCH-IgM negative pregnant women（P0.01）.Conclusion TORCH infection during pregnancy is correlated with adverse pregnancy outcome such as spontaneous abortion,premature delivery,and intrauterine death.