丹参注射液对重症急性胰腺炎患者血清细胞间黏附分子-1变化的影响

Effects of Danshen injection on the expression of intercellular adhesion molecule-1 in patients with severe acute pancreatitis

目的研究重症急性胰腺炎(SAP)患者血清细胞间黏附分子(ICAM-1)水平的变化特点及丹参对其作用。方法按照随机分组原则,将所有80名患者分为对照组和丹参治疗组。对两组患者的ICAM-1水平和相关临床资料进行比较。结果 A组患者第二天、第四天、第六天ICAM-1水平较B组均明显升高(均P<0.05);A组患者治疗前ICAM-1水平较B组比较差异无统计学意义(P>0.05);A组患者年龄、性别等与B组比较差异无统计学意义(均P>0.05)。结论丹参注射液可以抑制SAP患者ICAM-1水平,从而对SAP患者起到治疗作用。

OBJECTIVE To explore the changes of plasma intercellular adhesion molecule-1 （ICAM-1） as well as the effects of Danshen in patients with severe acute pancreatitis（SAP）. METHODS 80 patients with SAP Were collected. The patients were divided into routine treatment group （A group） and Danshen treatment group （B group）, the characters of clinical and the Level of ICAM-1 were compared between the two groups. RESULTS The lever of ICAM-1 were significantly higher in A group than that in B group in day 2 ,4 and 6 （ all P 〈 0. 05 ） ; the lever of ICAM-1 was no significant differences between group A and group B before the treatment（P 〉0. 05） ;there is no sig- nificant differences between group A and group B in Age,gender（ all P 〉 0. 05 ）. CONCLUSION Danshen injec- tion can effectively reduce the plasma levels of ICAM-1 in SAP patients, it plays a better therapeutic effect through improving mieroeirculation of SAP patients.