NSTEMI患者血清IL-6、cTnI和TNF-α检测的临床评价

Clinical Evaluation of Changes on Serum IL-6,cTnI and TNF-α Levels in Patients with Non-ST-Segment Elevation Myocardial Infarction(NSTEMI)

目的:探讨非ST抬高型急性心肌梗死(NSTEMI)患者血清IL-6、cTnI和TNF-α水平的变化的临床意义。方法:应用放射免疫分析和生化法对62例怀疑NSTEMI患者进行了血清IL-6、cTnI和TNF-α检测,并根据临床诊断分成观察组和对照组,进行统计学分析。结果:NSTEMI患者血清IL-6、cTnI和TNF-α水平均非常显著地高于对照组。且血清IL-6水平与cTnI和TNF-α水平呈显著正相关(r=0.5782、0.6024,P<0.01)。结论:血清IL-6、cTnI和TNF-α水平升高与NSTEMI的预测、诊断和预后均有一定的临床价值。

Objective To explore the significance of changes on the levels of serum IL-6, cTnI and TNF-α in patients with suspi- cious non-ST-segment elevation myocardial infarction（NSTEMI）. Methods Serum IL-6,TNF-α（with RIA） and serum cTnI（with bi-ochemistry） levels were measured in 62 patients who were suspected NSTEMI statistical analysis of observation group and control group divided by clinical diagnosis was conducted. Results The levels of serum IL-6, cTnI and TNF-α were significantly higher than those in controls（P 〈 0.01 ）. The levels of serum IL-6 was obviously positive correlated with the levels of cTnI, TNF-α（ r = 0. 5782 ,0. 6024 , P 〈 0.01 ）. Conclusion The changes of levels of serun IL-6, cTnI and TNF-α closely associated with NSTEMI, and might be of cer- tain clinical value of prediction, diagnosis and prognosis in patients with NSTEMI.