糖尿病视网膜病变患者血清IL-10、IL-18和E-选择素检测的临床意义

Clinical Significance of Measurement the Changes of Serum IL-10,IL-18 and E-selectin Levels in Patients with Diabetic Retinopathy

目的:探讨糖尿病视网膜病变患者血清IL-10、IL-18和E-选择素水平的变化及临床意义。方法:应用放射免疫分析和酶联法对32例无糖尿病视网膜病变患者,30例伴视网膜病变患者进行了血清IL-10、IL-18和E-选择素检测,并与35名正常健康人作比较。结果:糖尿病患者无论有无视网膜病变,患者血清IL-10、IL-18和E-选择素水平均显著地高于正常人组(P<0.01),血清IL-10水平与IL-18和E-选择素水平呈正相关(r=0.5084、06137,P<0.01)。结论:血清IL-10、IL-18和E-选择素参与了糖尿病视网膜病变的发病机制,检测血清IL-10、IL-18和E-选择素水平的变化有助于糖尿病视网膜病变的诊断,有一定的临床价值。

Objective To explore the clinical significance the measurement of changes of serum IL-10,IL-18 and E-selectin lev- els in patients with diabetic retinopathy. Methods Serum IL-10（with RIA）, serum IL-18, E-selectin（with ELISA）levels were meas- ured in 32（NDR）, 30（DR） and 35 normal healthy controls. Results Serum IL-10,IL-18 and E-selectin levels in the patients with NDR and DR were significantly higher than those in controls. Serum IL-10 level was positively correlated with serum IL-18 and E-se- lectin levels （r = 0. 5084 ,06137 ,P 〈 0.01 ）. Conclusion Serum IL-10, IL-18 and E-selectin play an important role in the pathogene- sis of diabetic retionpathy. Detection of serum IL-10, IL-18 and E-selectin levels will be helpful for the diagnosis and therapy of diabetic retinopathy, thus provide certain value clinically.