ACI患者血清NSE和血浆D-D、Fb相关性的分析

Study on the correlative Analysis of Serum NSE and Plasma D-dimer,Fibrinogen in Patients with Acute Cerebral Infarction

目的:叙述了急性脑梗死(ACI)患者血清神经元特异性烯醇化酶(NSE)和血浆D-二聚体(D-D)、纤维蛋白原(Fb)水平的变化及其之间的相关性。方法:采用化学发光法和免疫比浊法对34例ACI患者进行了血清NSE和血浆D-D、Fb检测,并与35名正常健康人作比较。结果:ACI患者血清NSE和血浆D-D、Fb水平均非常显著地高于正常人组(P<0.01)。血清NSE与血浆D-D、Fb水平呈正相关(r=0.4928、0.5012,P<0.01)结论:血清NSE和血浆D-D、Fb与ACI的发生、发展密切相关。三者联检对ACI的预防、治疗和预后均具有重要的临床意义。

Objective To explore the levels of serum NSE and plasma D-dimer（ D-D）, fibrinogen （Fb） in patients with acute cerebral infarction and the correlation among such laboratory items. Methods Serum NSE（with CLIA） ,plasma D-D and Fb（with im-munoturbidimetry） levels were determined in 34 patients with acute cerebral infarction and 35 normal healthy controls. Results Ser- um NSE and plasma D-D, Fb levels in the patients with ACI were significantly higher then those in controls （P 〈 0.01 ）. Serum NSE level was positively correlated with D-D, Fb levels（ r = 0.4928, 0.5012. ,P 〈 0.01 ）. Conclusion The serum NSE, plasma D-D and Fb levels are closely related to the occurrence of patients with ACI. The combined detection of NSE, D-D and Fb provides important clinical significance in the prevention, treatment and prognosis of ACI.