血浆NSE浓度与脑出血预后的相关性分析

Correlative Analysis of Plasma Neuron-specific Enolase Concentration and Prognosis of Intracerebral Hemorrhage

目的:检测脑出血患者血浆神经元特异性烯醇化酶(NSE)浓度,评价其与脑出血预后的相关性。方法:收集急性脑出血患者和同期健康体检正常人各98例,采用ELISA测定血浆NSE浓度,统计分析其与脑出血预后的相关性。结果:脑出血患者血浆NSE浓度(14.7±4.9)μg/L显著高于体检健康者(4.2±0.7)μg/L(P<0.01)。脑出血患者血浆NSE浓度与血肿量(r=0.621,P<0.01)及格拉斯哥昏迷评分(r=-0.595,P<0.01)显著相关,认定为脑出血患者3个月内死亡的独立危险因素(OR=1.231,95%CI=1.114～3.614,P<0.01),对脑出血3个月内死亡有显著预测价值(曲线下面积=0.881,95%CI=0.824～0.941,P<0.01)。结论:血浆NSE与出血性脑损伤程度显著相关,可正确预测脑出血死亡。

Objective This study aimed to determine plasma neuron-specific enolase （NSE） concentration in patients with in- tracerebral hemorrhage （ICH） and to evaluate its association with disease prognosis. Methods Ninety-eight ICH patients and 98 nor- mal healthy controls were enrolled into this study. Plasma NSE concentration was measured by ELISA. Its association with prognosis of ICH was analyzed statistically. Results Plasma NSE concentration was obviously higher in the patients than that of healthy controls （ 14.7 ± 4.9 μg/L vs. 4.2 ± 0.7 μg/L, P 〈 0.01 ）. Plasma NSE concentration of ICH patients was highly correlated with hematoma volume （r = 0.621, P 〈 0.01 ）and Glasgow coma scale （GCS） score（ r = -0.595, P 〈 0.01 ）, identified as an independent risk factor for 3-month mortality of patients （ OR = 1. 231, 95% CI = 1. 114 ~ 3. 614, P 〈0.01 ）, had significant predictive value for 3-month mortality of patients （ Area under curve = 0.881, 95% CI = 0. 824 ~ 0.941, P 〈 0.01 ）. Conclusion Plasma NSE concentration is highly correlated with severity of hemorrhagic brain injury, and can accurately predict death of ICH.