慢性支气管炎患者血浆L-selectin和TNF-α的检测及临床价值

Determination of Plasma L-selectin and Tumor Necrosis Factor-α Concentrations in Patients with Chronic Bronchitis and Its Clinical Values

目的:揭示慢性支气管炎患者血浆L-选择素(L-selectin)和肿瘤坏死因子-α(TNF-α)浓度的变化,探讨其临床价值。方法:收集慢性支气管炎患者和同期体检健康者各98例。ELISA检测血浆L-selectin和TNF-α浓度。结果:慢性支气管炎患者血浆L-selectin和TNF-α浓度均显著高于健康体检正常者(均P<0.01),急性发作期患者血浆L-selectin和TNF-α浓度均显著高于临床缓解期患者(均P<0.01),慢性支气管炎患者血浆L-selectin和TNF-α浓度与动脉血气指标显著相关(均P<0.01)。结论:L-selectin和TNF-α参与慢性支气管炎的病理生理过程,指标测定有助于评估慢性支气管炎病情轻重及预后。

Objective To explore plasma L-selectin and tumor necrosis factor-or levels in patients with chronic bronchitis and their clinical values were evaluated. Methods Ninety-eight patients and equal number of healthy controls were enrolled into this stud- y. Plasma L-selectin and tumor necrosis factor-or concentrations were measured by ELISA. Results Plasma L-selectin and TNF-α levels were markedly higher in patients with chronic bronchitis than those in healthy controls （ all P 〈 0.01 ）, and in acute exacerbation than in clinical recovery （ all P 〈0.01 ）. They were significantly associated with diverse variables of arterial blood gas （ all P 〈0.01 ）. Conclusion L-selectin and tumor necrosis factor-or are involved in the pathophysiological process of chronic bronchitis and their de- termination can be beneficial to evaluate severity and prognostication of chronic bronchitis.