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食管鳞状细胞癌组织中酸性富含半胱氨酸分泌型蛋白的表达与生存的相关性 被引量：2

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摘要 中国食管癌病死率居恶性肿瘤死亡的第4位，80％的患者确诊时已至中晚期，主要依靠化学和放射治疗及综合治疗，预后较差。食管鳞状细胞癌（esophageal squamous cell carcinoma，ESCC）是食管癌的主要组织类型。酸性富含半胱氨酸分泌型蛋白（secreted protein，acidic and rich in cysteine，SPARC）在多种肿瘤中高表达，并与患者预后相关[1]。Xue等[2]通过分析ESCC组织及其配对的相邻正常黏膜组织标本发现，SPARC在ESCC组织中过表达。本研究对ESCC组织中SPARC的表达与患者生存的关系进行探讨分析。
作者 杨锡贵 姜超 刘封 杨香山
机构地区 山东省肿瘤医院内科 山东省医学科学院附属医院(山东省肿瘤医院东院区)内科 山东省医学科学院附属医院(山东省肿瘤医院东院区)病理科 山东省曲阜市人民医院肿瘤科
出处 《中华消化杂志》 CAS CSCD 北大核心 2013年第3期197-198,共2页 Chinese Journal of Digestion
关键词 食管鳞状细胞癌组织 半胱氨酸 分泌型 蛋白 酸性 相关性 CARCINOMA 恶性肿瘤死亡
分类号 R735.1 [医药卫生—肿瘤]
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参考文献9

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同被引文献22

  • 1车轶群,王海,齐军,郭健,刘芝华.食管鳞癌组织中SPARC蛋白表达的临床意义[J].中国肿瘤临床,2006,33(2):61-63. 被引量：12
  • 2Termine JD,Kleinman HK,Whitson SW,et al.Osteonectin,a bonespecific protein linking mineral to collagen[J].Cell,1981,26(1:99-105.
  • 3Chlenski A,Cohn SL.Modulation of matrix remodeling by SPARC m neoplastic progression[J].Semin Cell Dev Biol,2010,21 (1):55-65.
  • 4Nagaraju GP,Sharma D.Anti-cancer role of SPARC,an inhibitor of adipogenesis[J].Cancer treat Rev,2011,37(7):559-566.
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  • 6Ledda MF,Adris S,Bravo AI,et al.Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells[J].Nature medicine,1997,3(2):171-176.
  • 7Yamashita K,Upadhay S,Mimori K,et al.Clinical significance of secreted protein acidic and rich in cystein in esophageal carcinoma and its relation to carcinoma progression[J].Cancer,2003,97 (10):2412-2419.
  • 8Porte H,Triboulet JP,Kotelevets L,et al.Overexpression of stromelysin-3,BM-40/SPARC,and MET genes in human esophageal carcinoma:implications for prognosis[J].Clinical cancer research,1998,4(6):1375-1382.
  • 9Brabender J,Lord RV,Metzger R,et al.Differential SPARC mRNA expression in Barrett's oesophagus[J].Br J cancer,2003,89(8):1508-1512.
  • 10Che Y,Luo A,Wang H,et al.The differential expression of SPARC in esophageal squamous cell carcinoma[J].Int J Mol Med,2006,17(6):1027-1033.

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中华消化杂志
2013年 第3期

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