摘要
巴喹普林是苄胺嘧啶类动物专用抗菌增效剂,具有广谱、活性高、消除缓慢的优点,其消除半衰期远优于甲氧苄胺嘧啶。在临床上巴喹普林与磺胺二甲基嘧啶等配成复方制剂,主要用于牛、猪、犬等动物感染性疾病的治疗,具有广阔的市场前景和研究价值。笔者对巴喹普林的抗菌活性、药动学特征、临床应用等进行了综述,旨在为该药的开发利用提供参考。
Baquiloprim(BQP),as a noval veterinary amiopyrimidine antibacterial synerists,has the advantages of broad spectrum,high activity,and slow elimination.The antibacterial spectrum of BQP is similar to the spectrum of trimethoprim(TMP),but the elimination half-life are much better.In clinic application,BQP is usually made compound preparations with sulfonamides,being used for the infectious diseases of cattle,pigs,dogs,etc.BQP has a good prospect in application and worths further studying.The antibacterial activity,pharmacokinetics and clinical application of BQP were summarized in order to provide reference for development and utilization of the BQP.
出处
《安徽农业科学》
CAS
2013年第6期2503-2504,2507,共3页
Journal of Anhui Agricultural Sciences
关键词
巴喹普林
抗菌活性
药动学
临床应用
Baquiloprim
Antibacterial activity
Pharmacokinetics
Clinical application