哮喘气道重塑与“痰瘀伏肺”相关性及蠲哮片干预作用初探

Preliminary discussion the correlation between asthma airway remodeling and ‘phlegm and stasis in lung’ and the intervention effect of Juanxiao Tablets

支气管哮喘(简称哮喘)是由多种细胞(如嗜酸性粒细胞、肥大细胞、T细胞、中性粒细胞、气道上皮细胞等)和细胞组分参与的气道慢性炎症性疾病,气道重塑是其重要的病理基础。笔者认为"痰瘀伏肺"是哮喘发病的宿根。痰瘀互结,气道狭窄,使病情迁延,缠绵难愈。痰瘀气阻的病理特征,与现代医学关于哮喘气道重塑细胞外基质沉积和平滑肌增生导致气流受限是一致的。本文就支气管哮喘气道重塑与"痰瘀伏肺"的相关性及涤痰行瘀方药(蠲哮片)干预气道重塑作用进行初步探讨。

Bronchial asthma（abbreviation： asthma） is composed of multiple cells,such as eosinophils,mast cells,T cells,neutrophils,airway epithelial cells,and cellular components involved in chronic inflammatory airway disease,airway remodeling is the important pathological basis.We believe that the ‘phlegm and stasis in lung’ is the onset of root.Phlegm and stasis combination makes airway stenosis,protract illness and touching refractory.The pathological features of phlegm stasis and pneumatic resistance are consistent with airflow limitation resulting from asthma airway remodeling of extracellular matrix deposition and smooth muscle hyperplasia in modern medicine.In this paper,we discussed preliminary the correlation between asthma airway remodeling and ‘phlegm and stasis in lung’,and the intervention effect of the phlegm and stasis-expelling prescription（Juanxiao Tablets） in airway remodeling.