壁虎抗肿瘤活性物质的发现及作用机制研究进展

Research progress and mechanism research on anti-tumor material finding from Gecko

壁虎广泛用于临床肿瘤疾病的治疗,因其抗肿瘤的独特疗效和低毒副作用,已经引起国内外学者的高度重视,近年来多个研究室对壁虎抗肿瘤的物质基础和作用机制进行了大量研究,取得了一定进展。文章综述了从壁虎中寻找活性物质的研究现状及分离到的抗肿瘤活性单体,总结了壁虎在诱导肿瘤细胞凋亡、抑制肿瘤新生血管形成、诱导肿瘤细胞分化以及免疫调节等方面的药理机制,并结合本课题组的工作对壁虎抗肿瘤研究进行了展望,以期为研究工作者的深入研究提供参考和依据。

Gecko is effective to cure many kinds of tumor with little toxicity.Many labs have tried to find the anti-tumor materials from gecko.The anti-tumor mechanism of gecko has also been deeply investigated.This paper reviewed the advances on the active materials finding and the active monomer isolated from gecko and its anti-tumor mechanisms.Gecko played the antitumor roles from several different ways which include inducing cells apoptosis,inhibiting tumor angiogenesis,promoting the cell differentiation and stimulating immunity.And we looked forward to the anti-tumor research of gecko.This review provided a reference for the further study of the Gecko anti-tumor.