类风湿关节炎相关肺间质病变中医证候特征回顾性分析

Retrospective analysis for TCM symptoms characteristic of interstitial lung disease associated with rheumatoid arthritis

目的:分析类风湿关节炎相关肺间质病变(RA-ILD)患者的中医证候特征。方法:运用回顾性研究的方法,总结68例RA-ILD患者,分析合并疾病、肺损伤程度、中医证候特征。结果:RA-ILD常合并贫血、干燥综合征、肺部感染等;有呼吸道症状43例;肺部HRCT表现以磨玻璃样变、网格状影及蜂窝样改变为主;肺功能主要表现为通气功能或弥散功能障碍。证候方面:以肺、脾、肾为主,主要以气虚及阴虚为主。标实证多见痰瘀证、痰热证、痰湿证。结论:RA-ILD以本虚标实为主,肺肾气阴两虚证合并痰瘀证为主要证候类型。

Objective： To investigate the syndrome rules of rheumatoid arthritis-interstitial lung disease（RA-ILD）.Methods： A retrospective study of 68 patients with RA-ILD were performed.The patients informations including the clinical symptoms,complications,lung HRCT,pulmonary function,experiments results,et al.Results： The complications of RA-ILD mainly included anemia,sjogren＇s syndrome,lung infection.In addition to,we found that pulmonary HRCT,pulmonary function,ESR and CRP show a significant positive correlations with the disease.The common syndrome types of RA-ILD included arthritis,fatigue,shortness of breath,cough,dry mouth,weigh loss,and et al.The main syndrome types of deficiency of the root included qi deficiency,yin deficiency,lung-kidney qi-yin deficiency.The main syndrome types of excess in superficiality included phlegm and blood,phlegm and heat,phlegm and wet.Conclusion： We believe that the basic pathology of RA-ILD is deficiency in origin and excess in superficiality,and the main syndrome type is lung-kidney qi-yin deficiency and stagnation of phlegm and blood.