摘要
目的:探讨TUBB3(Ⅲ型β微管蛋白3)蛋白在食管鳞癌及癌旁正常组织中的表达及临床意义。方法:免疫组化法检测50例食管鳞癌及癌旁正常组织中TUBB3蛋白的表达,分析TUBB3蛋白表达与临床病理因素的关系。结果:TUBB3蛋白在食管鳞癌组织中表达率64%明显高于癌旁正常组织14%(P<0.05)。TUBB3蛋白在Ⅲ期食管癌中的阳性表达率高于Ⅰ-Ⅱ期(P<0.05),在高分化食管癌中的阳性表达率明显低于中、低分化食管癌(P<0.05)。TUBB3蛋白的表达与患者的年龄、性别、浸润深度以及淋巴结转移无明显关系(P>0.05)。结论:TUBB3蛋白表达在食管癌的发生、发展中有一定作用,其检测有助于食管癌诊断、治疗及预后评估。
Objective:To explore the expression of Ⅲβ -tubulin protein in patients with esophageal carcinoma, and to clarify its clinical significance. Methods: Samples of 50 cases of esophageal carcinoma were collected after operation,were investigated for the expression of Ⅲβ -tubulin protein by immunohistochemistry. The relationship between the expression of Ⅲβ - tubulin and the biological features of esophageal carcinoma was analyzed. Results: The positive rate ofⅢβ - tubulin protein in esophageal carcinoma tissues was higher than that in normal tissues ( P 〈 0.05). The expression of Ⅲβ - tubulin in stage Ill cases was higher than in stage I - II cases ( P 〈 0.05 ). The positive rate of Ⅲβ - tubulin in well pathological grades was lower than in moderate - poor ones ( P 〈 0.05 ). The positive rate of expression of TUBB3 was not correlated with sex, age, depth of invasion and lymph node metastasis (P 〉 O. 05). Conclusion:The expression ofⅢβ -tubulin may play an important role in the development and progression of esophageal carcinoma, and could be an important index for the prognosis of esophageal carcinoma.
出处
《现代肿瘤医学》
CAS
2013年第4期754-756,共3页
Journal of Modern Oncology
基金
吴阶平医学基金会科研专项资助基金(编号:320.6700.1173)
关键词
TUBB3
食管癌
预后
免疫组织化学
TUBB3
esophageal carcinoma
prognosis
immunohistochemistry