结直肠癌患者血清cathepsin S水平检测及其临床意义

Detection of serum cathepsin S in patients with colorectal cancer and its clinical significance

目的探讨结直肠癌患者血清组织蛋白酶S(cathepsin S)水平及其临床意义。方法采用ELISA检测98例结直肠癌患者术前、术后血清cathepsin S水平,并以50例健康者作为对照组。结果结直肠癌患者术前、术后血清cathepsin S水平均高于对照组(P<0.05)。术前结直肠癌患者血清cathepsin S水平高于术后(P<0.05)。随着Duke's分期的深入,结直肠癌患者血清cathepsin S水平也逐步升高(均P<0.05)。相关性分析提示,结直肠癌患者血清cathepsin S水平与Duke's分期呈显著正相关(r=0.367,P<0.05)。结论血清cathepsin S水平与结直肠癌的发生、发展有关联,与Duke's分期显著相关,可作为结直肠癌术后随访观察及判断预后的备选指标。

Objective To investigate the level of serum cathepsin S in patients with colorectal cancer and its clinical significance. Methods The level of serum cathepsin S before and after operation in 98 patients with colorectal cancer was compared with that in 50 control （healthy） subjects by ELISA. Results The level of serum cathepsin S in patients with colorectal cancer was significantly higher than that in control group both before and after operation （ P 〈 0.05 ）. The level of serum cathepsin S before operation was significantly higher than that after operation （P 〈 0.05 ）. With the progression in Duke＇s staging, the serum cathepsin S level in patients with colorectal cancer gradually increased （ P 〈 0.05 ） ; the serum cathepsin S level has positive correlation with Duke＇s staging（ r = 0. 367 ,P 〈 0.05 ）. Conclusion The level of serum cathepsin S is associated with colorectal cancer occurrence and development and significantly correlated with Duke＇s staging. It can be a candidate indicator for follow-up observation of colorectal cancer and prognosis.