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白细胞介素33在IBD炎症进展和黏膜愈合中的作用 被引量：2

Role of Interleukin 33 in the Inflammation Progress and Mucosal Healing of IBD
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摘要 炎症性肠病(IBD)主要包括溃疡性结肠炎(UC)和克罗恩病(CD),近年其发病呈上升趋势。IBD的发病机制尚不明确,研究表明免疫炎症反应起重要作用。白细胞介素33(IL-33)是新近发现的炎症因子,越来越多证据表明其参与IBD发病。本文就IL-33在IBD炎症进展和黏膜愈合中的作用作一综述。 Inflammatory bowel disease （IBD） consists of ulcerative colitis （UC） and Crohn＇ s disease （CD）. The incidence of IBD has increased in recent years, but the etiology is still unclear. Many studies have proved that immune inflammatory response plays a critical role in the development of IBD. Interleukin 33 （IL-33） is a recently discovered inflammatory factor, more and more studies suggest it contributes to the development of IBD. This article reviewed the role of IL-33 in inflammation progress and mucosal healing of IBD.
作者 杨庆帆 曾志荣
机构地区 中山大学附属第一医院消化内科
出处 《胃肠病学》 2013年第2期118-121,共4页 Chinese Journal of Gastroenterology
关键词 结肠炎 溃疡性 CROHN病 白细胞介素33 炎症 黏膜愈合 Colitis, Ulcerative Crohn Disease Interleukin 33 Inflammation Mucosal Healing
分类号 R574.62 [医药卫生—消化系统]
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参考文献31

  • 1Thia KT, Loftus EV Jr , Sandborn WJ, et al. An update on the epidemiology of inflammatory bowel disease in Asia [J]. Am J Gastroenterol, 2008,103 (12): 3167-3182.
  • 2Prefontaine D, Lajoie-Kadoch S, Foley S, et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells [ J]. J Immunol, 2009,183 (8): 5094-5103.
  • 3Matsuyama Y, Okazaki H, Tamemoto H, et al. Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis [J]. J Rheumatol, 2010, 37 (1): 18-25.
  • 4Mok MY, Huang FP, Ip WK, et al. Serum levels of IL-33 and soluble S1'2 and their association with disease activity in systemic lupus erythematosus [J]. Rheumatology ( Oxford) , 2010, 49 (3) : 520-527.
  • 5Yanaba K, Yoshizaki A, Asano Y, et al. Serum 11-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis [ J]. Clin Rheumatol, 2011, 30 (6) : 825 -830.
  • 6Turnquist HR, Zhao Z, Rosborough BR, et al. IL-33 expands suppressive CDI1 b + Gr-1 ( int ) and regulatory T cells, including S1'2L + Foxp3 + cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival[J]. J Immunol, 2011, 187 (9): 45984610.
  • 7Baekkevold ES, Houssigne M , Yamanaka T, et al. Molecular characterization of NF - HEV, a nuclear factor preferentially expressed in human high endothelial venules [ J ]. Am J Pathol, 2003, 163 (1) : 69-79.
  • 8Schmitz J, Owyang A, Oldham E, et al. IL-33 , an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein S1'2 and induces T helper type 2- associated cytokines [ J ] . Immunity, 2005, 23 (5): 479490.
  • 9Seidelin JB, Bjerrum JT, Coskun M, et al. IL-33 is upregulated in colonocytes of ulcerative colitis [ J ]. ImmunolLett, 2010,128 (1): 80-85.
  • 10Cayrol C, Girard JP. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1 [ J]. Proc Natl Acad Sci USA, 2009, 106 (22) : 9021-9026.

同被引文献28

  • 1Zeng Z, Zhu Z, Yang Y, et al. Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong Province, China: a prospective population-based study [J]. J Gastroenterol Hepatol, 2013,28(7) :1148-1153.
  • 2Carriere V, Roussel L, Ortega N, et al. IL-33 , the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo [J]. Proc Natl Acad Sci USA, 2007, 104(1) :282-287.
  • 3Palmer G, Lipsky BP, Smithgall MD, et al. The IL-I receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 [J]. Cytokine, 2008, 42 (3): 358- 364.
  • 4Prefontaine D, Lajoie-Kadoch S, Foley S, et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells [J]. J Immunol, 2009, 183(8) :5094-5103.
  • 5Matsuyama Y, Okazaki H, Tamemoto H, et al. In- creased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis [J]. J Rheumatol, 2010, 37(1) :18-25.
  • 6Kobori A, Yagi Y, Imaeda H, et al. Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis [J]. J Gastroenterol, 2010, 45 (10) : 999-1007.
  • 7Seidelin JB, Bjerrum JT, Coskun M, et al. IL-33 is upregulated in colonocytes of ulcerative colitis [J]. Immunol Lett, 2010,128(1) :80-85.
  • 8unisch E, Chakilam s, Gandesiri M, et al. IL-33 regu-lates TNF -alpha dependent effects in synovial fibroblasts [J]. Int J Mol Med, 2012, 29(4) :530-540.
  • 9Latiano A, Palmieri 0, Pastorelli L, et al. Associations between genetic polymorphisms in IL-33, ILIRI and risk for inflammatory bowel disease [J]. PLoS One, 2013, 8 (4) :e62144.
  • 10Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology [J]. Can J Gastroenterol, 2005, 19 (Suppl A) : 5A-36A.

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胃肠病学
2013年 第2期

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