基于原子力显微镜对多肽自组装结构的纳米操纵研究

Mechanical nanomanipulation of individual peptide nanofilaments based on AFM

多肽自组装作为一种"自下而上"的技术得到了快速的发展,所形成的自组装结构作为新型的纳米材料具有众多潜在的应用。然而在多肽自组装过程中,会产生各种各样的缺陷,导致多肽纤维形成的图案有一定的局限性。本文利用原子力显微镜对固液界面生长的多肽自组装结构进行纳米操纵,介绍了定位移除部分多肽纤维从而产生缺口的方法,并利用所产生的缺口实现了纳米纤维的重新排布,极大地提高了多肽纳米纤维构成图案的复杂性,在纳米制造中有潜在的应用。

The rapidly developing peptide self-assembly is a ＂bottom to up＂ technology that has potential applications in nanomanufacturing.However,the normally self-assembled peptide structures contain some defects.In addition,the patterns formed by the assembled peptide structures on solid surfaces are limited.In this paper,we report that atomic force microscope（AFM）-based mechanical operation can be used to manipulate individual peptide filaments.Positioning removing a part of the pre-formed peptide nanofilaments was achieved,which resulted in gaps on the peptide filaments.By increasing the peptide concentration,the gaps could be filled by peptide monomers.By removing junction part of two peptide filaments,the extending of the filaments could be restored,so that a crossed pattern was formed.With the AFM nanomanipulation method,complicated patterns formed by individual peptide filaments could be obtained,which has potential applications in nanomanufacturing.