七氟醚预处理对妇科腔镜患者肺保护的影响

Lung Protection Effect of Sevoflurane Pretreatment on Patients with Gynecological Telescopy

目的观察七氟醚预处理对妇科腔镜患者肺保护的影响.方法择期妇科腔镜手术患者60例,随机分为七氟醚组(S组)和对照组(T组),每组30例.S组诱导前先给予1%～2%七氟醚吸入30 min,T组静脉丙泊酚维持30 min,然后采用相同诱导方法气管插管全麻,在诱导前(T1),气腹充好后(T2),气腹结束(T3),手术结束后30 min(T4)分别抽取患者静脉血6 mL,检测血清丙二醛(MDA)和内皮素(ET)的含量.结果相比P组,S组T2,T3,T4的MDA和ET的含量减少(P<0.05).2组内比较,P组T2,T3相比T1有升高(P<0.05),S组T2,T3有升高但无统计学差异(P>0.05).结论七氟醚预处理通过减少妇科腔镜患者血液MDA的产生,稳定ET的含量,减少肺的氧化损伤,稳定血流,从而起到肺保护的作用.

Objective To observe the lung protection effect of sevoflurane pretreatment on patients with gynecological telescopy.Methods 60 patients with gynecological telescopy were selected and randomly divided into 2 groups： Sevoflurane group（group S） and control group（group P）,and 30 cases in each group.Patients in S group were given 1%-2% sevoflurane inhalation for 30 min before induction,patients in P group were given propofol for 30 min before induction,and then general anesthesia was induced with the same method of endotracheal intubation.The blood samples of patients in two groups were collected to detect the serum malondialdehyde（MDA） and endothelin（ET） content before induction（T1）,after pneumoperitoneum（T2）, pneumoperitoneum end（T3）,30 min after the surgery（T4）.Results Compared with group P,the serum MDA and ET content in S group decreased at T2,T3 and T4（P0.05）.And in group P,the serum MDA and ET content at T1 were lower than those at T2 and T3（P0.05）.In group S,the serum MDA and ET content at T2 and T3 were a little higher than those at T1,while the difference had no statistical significance（P0.05）. Conclusion Sevoflurane pretreatment can protect the lung function of patients with gynecological telescopy by reducing serum MDA production,stabilizing ET content,reducing lung oxidative damage and stabilizing blood flow.