C-12蛋白芯片检测宣威地区肺癌的临床意义

Clinical Significance of C-12 Protein Chip in Detection of Lung Cancer in Xuanwei Region

目的探讨C-12蛋白芯片对云南省宣威地区肺癌患者的诊断价值.方法 (1)应用C-12蛋白芯片检测系统分别检测实验组40例肺癌患者,对照组38例肺良性病变血清中12种肿瘤标志物(CA-199、NSE、CEA、CA-242、CA-125、CA-153、AFP、Feritin、free-PSA、PSA、β-HCG、HGH)的水平.分别计算出实验组和对照组血清C-12的阳性率及临床评价指标.结果实验组的C-12的阳性率为75%(30/40),显著高于对照组的36.84%(14/38),肺癌组中CEA、CA-199、CA-125、CA-242、CA-153血清水平显著高于肺良性病变组.C-12蛋白芯片检测的敏感度为75%(30/40),特异性为63.16%(24/38),准确度为69.23%(54/78).结论云南省宣威地区肺癌患者血清中CEA、CA242、CA125、CA153、CA199阳性率较高.C-12蛋白芯片检测对其有重要的辅助诊断价值.C-12蛋白芯片检测特异度较高,操作方便,费用低廉,可以用于该地区高危人群、住院患者的筛查.

Objective To investigate the diagnostic value of C-12 protein chip in detecting lung cancer patients in Xuan Wei region,Yunnan province.Methods The serum levels of l2 tumor markers,including CA199,NSE,CEA,CA242,CA125,CAl53,AFP,ferritin,free-PSA,PSA,β-HCG and HGH,were measured in 40 cases with lung cancer as trial group,38 cases with benign pulmonary lesion by the C-12 protein chip.The positive rate and clinical evaluation indexes of C-12 in trial group and benign pulmonary lesion group were calculated.Results The positive rates of C-12 were 75%（30/40） and 36.84%（14/38） in trial group and benign pulmonary lesion group,respectively.The trial group had significantly higher positive rate than benign pulmonary lesion group.The serum levels of the tumor of markers,including CEA,CA-199,CA-125,CA242,CA-153 in the trial group is significantly higher than the benign pulmonary lesion group.The sensitivity rate of C-12 was 75%（30/40）,the specificity rate of C-12 was 63.16%（24/38）,and the accuracy rate of C-12 was 69.23%（54/78）.Conclusions The positive rates of CEA,CA242,CA125,CA153,CA199 is higher in lung cancer patients in Yunnan Xuanwei region.C-12 protein chip has important diagnostic value for lung cancer.C-12 protein chip has high specificity,easy operation,and low expense,so can be used to screen lung cancer in high risk population and hospitalized patients in this region.