耐亚胺培南铜绿假单胞菌的耐药分析

Drug-resistant Analysis of Imipenem-resistant Pseudomonas Aeruginosa Strains

目的分析耐亚胺培南铜绿假单胞菌(IRPA)的耐药情况.方法对2008年1月至2011年12月住院患者临床标本中分离的267株耐亚胺培南假单胞菌的检出部位、科室、抗生素的耐药情况进行分析.结果IRPA主要来源于ICU科、呼吸内科、神经内科、神经外科、骨科的患者,其中痰标本中最多,占89.89%;对亚胺培南、氯霉素、氨苄西林三种抗生素的耐药率为100%;对阿莫西林/克拉维酸、四环素、头孢噻肟的耐药率在90%以上;阿米卡星耐药率最低,为26.97%.结论 IRPA感染的治疗较困难且会增加患者的病死率,在临床治疗时应引起足够的重视,选择适合的治疗措施及抗菌药物.

Objective To analyze the drug-resistance of imipenem-resistant Pseudomonas aeruginosa strains.Method We analyzed the detection samples,department,antibiotics resistance of 267 imipenem-resistant Pseudomonas aeruginosa strains isolated from clinical specimens of patients from January 2008 to December 2011.Results IRPA came mainly from such departments as ICU,Respiratory internal medicine, Neurology,Neurosurgery,Orthopaedics.Sputum specimens were the most,accounted for 89.89%.The resistance rate to Imipenem,chloramphenicol,and ampicillin was 100%,the resistance to Amoxicillin,tetracycline and cefotaxime was over 90%,while the resistance to amikacin was the lowest,only 26.97%.Conclusion As IRPA infection can cause high mortality and the treatment is difficult,the clinical treatment should be paid enough attention,effective treatment measures and antibiotics should be selected.