HIV-1Tat蛋白改变血脑屏障结构和功能的研究进展

Progress in Alteration of Blood-brain Barrier Function by HIV-1Tat Protein

HIV-Tat蛋白是人类免疫缺陷病毒-1型(HIV-1)基因编码的一种被称为反式转录激活因子,是HIV转录和复制所必须的一个很重要的调控蛋白.艾滋病痴呆以及艾滋病相关性脑炎的患者其血脑屏障(blood-brain barrier,BBB)都受到不同程度的损伤,其中HIV-1 Tat蛋白起到了非常重要的作用.然而HIV-Tat蛋白改变血脑屏障结构和功能并不清楚,本综述主要讨论HIV-1 Tat蛋白对血脑屏障结构和功能的影响.

HIV-Tat protein is the human immunodeficiency virus type-I （HIV-I） , a gene encoding is called trans-activator of transcription, is a necessary regulatory protein for transcription and replication of HIV. The blood brain barrier （BBB） is damaged in the AIDS correlated dementia （ADC） and HIV-associated encephalitis （HIVE）, HIV-Tat protein is believed to play an important role in the process. The mechanism HIV-! Tat protein in alteration of blood-brain barrier function is not entirely clear. The paper reviews the alteration of blood-brain harrier function by HIV-1 Tat protein to provide reference materials for related research and AIDS prevention and treatment.