吸入混合气BOLD-fMRI对正常前列腺组织加龄性变化的研究

The study of aging change of normal prostate using carbogen-breathing BOLD-fMRI

目的通过比较正常前列腺志愿者吸入carbogen气体后不同年龄组正常中央腺区(CZ)和周围带(PZ)的相对信号强度平均增加率,探讨正常前列腺不同组织SI-TC的加龄性变化特征。方法本研究纳入正常前列腺志愿者32例,按年龄分为<30岁,30～50岁和>50岁三组。吸入carbogen气体状态下行BOLD-fMRI成像。分别记录吸入carbo-gen气体前、后的CZ和PZ的平均信号强度值,计算吸入carbogen气体后相对信号强度平均增加率;比较不同年龄段CZ和PZ相对信号强度平均增加率之间的差别。结果 <30岁年龄组的CZ相对信号强度平均增加率高于>50岁年龄组(P=0.014);<30岁年龄组的PZ相对信号强度平均增加率高于30～50岁年龄组和>50岁年龄组,差异均具有统计学意义(P=0.015;P=0.007)。结论吸入carbogen气体状态下BOLD-fMRI信号改变能反映正常前列腺组织的加龄性变化规律,可为前列腺疾病发生机制的研究提供新的手段。

Objective The relative increase signal average rate in normal prostate central zone tissue(CZ),peripheral zone tissue(PZ) using blood oxygen level-dependent(BOLD) induced by carbogen(95% O2/ 5% CO2) breathing were analyzed.The objective of this study was to explore the changes of signal intensity-time curve(SI-TC) in CZ and PZ of different age.Methods BOLD-fMRI was performed using a 3.0 Tesla superconducting magnetic scanner(GE) in 32 healthy volunteers and the volunteers were divided into three groups according to the age: under 30 years old,30-50 years old and above 50 years old.The average signal values of CZ and PZ before/after carbogen breathing and the relative increase signal average rate were computed.Results There was statistical significance between every two groups.The relative increase signal average rate of CZ under 30 years old was higher than that of above 50 years old(P=0.014).The relative increase signal average rate of PZ under 30 years old was higher than that of between 30-50 years old,but lower than that of above 50 years old(P=0.015;P=0.007).Conclusion BOLD-fMRI during carbogen breathing can reflect the signal change of normal prostate which may provide a new method to study the mechanism of prostate disease.