广西贵港地区乙型肝炎病毒感染及肝细胞性肝癌家族史与肝细胞性肝癌患者住院年龄的相关性分析

Analysis of potential associations of hepatitis B virus infection and family history of hepa-tocellular carcinoma with age at liver cancer diagnosis in Guigang city

目的通过对肝细胞性肝癌(hepatocellular carcinoma,HCC)住院病例的调查,探讨广西贵港地区乙型肝炎病毒(简称乙肝)感染及HCC家族史与HCC患者住院年龄的关系。方法应用临床流行病学横断面的研究方法,以2004～2008年贵港市人民医院首次住院的HCC患者1365例为研究对象。回顾性构建调查表的数据库,对贵港地区乙肝感染及HCC家族史与HCC患者住院年龄进行相关性分析。结果 HCC家族史(+)者住院年龄较HCC家族史(-)者小(P<0.05);HCC病例中乙肝(-)者住院年龄与乙肝(+)者的差异无统计学意义(P=0.738);以乙肝(-)且HCC家族史(-)者作为参照组,乙肝(+)且HCC家族史(-)组与之比较,患者住院年龄的差异无统计学意义(P=0.443),乙肝(-)且HCC家族史(+)者及乙肝(+)且HCC家族史(+)者的住院年龄均偏小(P均<0.05)。结论①无论是否有乙肝感染,HCC家族史(+)的肝癌患者住院年龄均较HCC家族史(-)者小;②HCC家族史及乙肝感染史与贵港地区HCC患者的住院年龄有关系。

Objective To explore potential associations of HBV infection and family history of hepatocellular carcinoma （HCC） with age at HCC diagnosis. Methods A total of 1 365 new patients with HCC treated between 2004 and 2008 at the People＇s Hospital of Guigang were included in a cross-sectional study, and data were analyzed retrospectively using Excel. Results Patients with a family history of HCC presented the disease at a signif-icantly earlier age than did those with no family history（P〈0.O5）.Age at diagnosis did not differ significantly between patients who were HBsAg-negative and patients who were HBsAg-positive （P=0.738）.Among patients with no family history of HCC,age at HCC diagnosis did not differ significantly between those who were HBsAg-positive and those who were HBsAg-negative （P=0.443）. However,age at HCC diagnosis of patients with a family history of the disease, regardless of their HBsAg status,was significantly lower than that of HBsAg-negative patients with no family history（P〈0.05）. Conclusion Among patients with HCC in Guigang City,those with a family history of the disease are diagnosed at an earlier age than are those with no family history,regardless of their HBsAg status.