年龄相关性脑白质改变：影像学、危险因素和临床意义

Age-related white matter changes： hnaging, risk factors and clinical significance

年龄相关性脑白质改变（age—related white matter changes，ARWMC）被认为是小动脉硬化性小血管病的表现，与高龄和血管危险因素有关。脑白质改变（white matter changes，WMC）已被公认为脑小血管病的表现之一，是老年人认知损害和功能丧失的病理学基础。研究表明，但WMC发展到一定程度时，会出现许多临床症状，包括认知损害、痴呆、抑郁、步态障碍、尿失禁，并与卒中和死亡风险增高相关。

Age-related white matter changes are considered as a manifestation of arteriolosclerotic small vessel disease and are associated with advanced age and vascular risk factors. White matter changes have been recognized as one of the manifestations of cerebral small vessel disease. They are the pathological basis of cognitive impairment and functional loss in the elderly. Studies have shown that when white matter changes develop to a certain extent, there will be many clinical symptoms, including cognitive impairment, dementia, depression, gait disturbances, and urinary incontinence, and they are associated with the increased risks of stroke and death.