期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PI3K／Akt信号通路与神经保护 被引量：7

PI3K/Akt signaling pathway and neuroprotection
原文传递
导出
摘要 PI3K／Akt通路是由磷脂酰肌醇3-激酶（phosphatidy linositol 3-kinase，PBK）始动的生物信号转导通路，在细胞增殖、细胞周期调控、凋亡启动、血管生成等方面发挥着关键作用。此外，PI3K／Akt通路还与中枢神经系统损伤的保护机制密切相关。深入研究PI3K／Akt、下游分子及其调控机制可能为脑损伤的治疗提供新的思路和方法。 PI3K/Akt pathway is a biological signal transduction pathway activated by phosphatidyli- nositol 3-kinase （PI3K）. It plays a key role in cell proliferation, cell-eycle regulation, apoptosis initiation, and angiogenesis. In addition, the PI3K/Akt pathway is closely associated with the protection mechanisms of central nervous system damage. In-depth study of PI3K/Akt, downstream molecules and their regulation mechanisms, can provide some new ideas and methods for the treatment of brain injury.
作者 杨帆 周其全
机构地区 第三军医大学高原军事医学系高原疾病学教研室
出处 《国际脑血管病杂志》 北大核心 2013年第2期143-147,共5页 International Journal of Cerebrovascular Diseases
基金 国家科技支撑计划课题（2009BAI85B03） 军队十一五攻关课题（2009G093）
关键词 磷脂酰肌醇3-激酶类 原癌基因蛋白质c-akt 脑缺血 血脑屏障 神经保护药 Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Brain Ischemia Blood- Brain Barrier Neuroprotective Agents
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献33

  • 1Hers T, Vincent EE, TavareJM. Akt signalling in health and disease. Cell Signal, 2011, 23: 1515-1527.
  • 2Hemming> BA. PtdTns(3,4,5)P3 gets its message across. Science, 1997,277: 534.
  • 3Urn SH, D'Alessio D, Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6Kl. Cell Metab, 2006, 3: 393-402.
  • 4Zha X, Hu Z, He S, WangF, et al. TSCIITSC2 inactivation inhibits AKT through mTORCI-dependent up-regulation of STAT3-PTEN cascade. Cancer Lett, 2011,313: 211-217.
  • 5Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell, 2012, 149: 274-293.
  • 6DeYoungMP, Horak P, Sofer A, et al. Hypoxia regulates TSCI/2- mTOR signaling and tumor suppression through REDDl-mediated 14-3-3 shuttling. Genes Dev, 2008, 22: 239-251.
  • 7TanJ, Geng L, Yazlovitskaya EM, et al. Protein kinase B/Akt?dependent phosphorylation of glycogen synthase kinasc-J Js in irradiated vascular endothelium. Cancer Res, 2006, 66: 2320-2327.
  • 8Shimura T. Acquired radioresistance of cancer and the AKT IGSK3131 cyclin Dl overexpression cycle.J Radiat Res, 2011, 52: 539-544.
  • 9Chuenkova MV, Pereiraperrin M. Neurodegeneration and neurore?generation in Chagas disease. Adv Parasitol, 2011, 76: 195-233.
  • 10Wong K, ZhangJ, Awasthi S, et al. Nerve growth factor receptor signaling induces histone acety!transferase domain-dependent nuclear translocation of p300lCREB-binding protein-associated factor and hGCN5 acety!transferases.J Bioi Chern, 2004, 279: 55667-55674.

二级参考文献40

  • 1Fisher JW. A quest for erythropoietin over nine decades. Annu Rev Pharmacol Toxicol, 1998; 38: 1 - 20.
  • 2Chikuma M, Masuda S, Kobayashi T, et al. Tissue-specific regulation of erythropoietin production in the murine kidney, brain and uterus. Am J Physiol Endocrinol Metab, 2000; 279:E1242 -E1248.
  • 3Juul SE, Anderson DK, Li Y, et al. Erythropoietin and erythropoietin receptor in the developing human central nervous system. Pediatr Res, 1998; 43:40-49.
  • 4Masuda S, Nagao M, Takahata K, et al. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem, 1993; 268:11208-11216.
  • 5Digicaylioglu M, Bichet S, Marti HH, et al. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci USA, 1995; 92:3717 -3720.
  • 6Morishida E, Masuda S, Nagao M, et al. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience, 1997; 76: 105 - 116.
  • 7Marti HH, Wenger RH, Rivas LA, et al. Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci,1996; 8:666-676.
  • 8Chin K, Yu X, Beleslin-Cokic B, et al. Production and processing of erythropoietin receptor transcripts in brain. Brain Res Mol Brain Res 2000; 81:29-42.
  • 9Juul SE, Anderson DK, Li Y. et al. Erythropoietin and erythropoietin receptor in the developing human central nervous system. Pediatr Res, 1998; 43: 40 -49.
  • 10Bernaudin M, Bellail A, Marti HH, et al. Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 2000; 30: 271 - 278.

共引文献3

同被引文献79

  • 1李永进,毕晓颖,宋春梅,马洪波,王长文,李志超.甲基汞对PC12细胞分化及活性的影响[J].吉林医药学院学报,2005,26(4):187-189. 被引量：1
  • 2曾文钦,刘钦,姚前尹,程亚涛,戴景兴,原林.内源性IGF-1有利于短暂脑缺血损伤新生大鼠海马神经发生[J].广州医学院学报,2014,42(1):5-9. 被引量：2
  • 3谢惠芳,徐如祥,陈中灿.线栓法制作大鼠局灶性脑缺血再灌注损伤模型的改进[J].中华神经医学杂志,2007,6(4):340-342. 被引量：28
  • 4霍超,徐桂花.枸杞生理功效和活性成分的研究进展[J].中国食物与营养,2007,13(11):50-53. 被引量：46
  • 5Premkumar IS, Pabbidi RM. Diabetic peripheral neuropa- thy: role of reactive oxygen and nitrogen species [ J ]. Cell Bioehem Biophys, 2013, 67 (2) : 373-383.
  • 6Gao J, Li J, An Y, et al. Increasing effect of Tangzhiqing formula on IRS-I-dependent PI3 KI AKT signaling in muscle [J]. BMC Complement Altern Med, 2014, 14:198.
  • 7Yang RH, Lin J, Hou XH, et al. Effect of docosahexaenoic acid hippocampal neurons in high-glucose condition: involvement of PI-3K1 Akt/nuclear faotor-xll-mediated inflammatory pathways[J]. Neuroscience, 2014, 274: 218- 228.
  • 8Leinninger GM, Backus C, Uhler MD, et al. Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons[J]. FASEB 1, 2004,18(13) :1544-1546.
  • 9Vareniuk I, Pavlov lA, Obrosova IG. Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin induced mouse mdel of diabetes [J] . Diabetologia, 2008, 51 ( 11 ) :2126-2133.
  • 10Rameau GA, Tukey DS, Garcin-Hosfield ED. Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death [J]. J Neuroscience, 2007, 27 (13) :3445-3455.

引证文献7

二级引证文献39

国际脑血管病杂志
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部