新诊断2型糖尿病并非酒精性脂肪性肝病患者颈动脉内膜中层厚度与血浆内脂素及游离脂肪酸水平的关系

检测49例新诊断T2DM并非酒精性脂肪肝病患者(NAFLD组),2型糖尿病无大血管病变组54例(T2DM组),健康对照组35名的颈动脉内膜中层厚度与血浆内脂素(Visfatin)、游离脂肪酸(FFA)和相关临床指标。结果:T2DM患者血浆Visfatin、FFA水平高于正常对照组(P<0.05),T2DM+NAFLD组血浆Visfatin、FFA水平较正常对照组升高(P<0.01);而T2DM+NAFLD组、T2DM组、正常对照组中Visfatin水平依次升高,组间统计存在显著性差异(P<0.001)。多元线性逐步回归分析显示腰臀比和空腹血糖是影响血浆Visfatin及FFA水平的独立相关因素。结论:血浆内脂素、游离脂肪酸水平变化与糖脂代谢关系密切,它在T2DM并NAFLD患者的大血管病变发病机制中起着一定作用。

Objective To investigate the change of plasma visfatin and free fatty acids （FFA） levels in patients with newly diagnosed type 2 diabetes mellitus （T2 DM）. Methods：Plasma visfatin and FFA concentrations and clinical indicators were meas- ured in 46 patients with newly diagnosed T2DM combined with NAFLD （ TEDM ＋ NAFLD group） ,54 patiests with simply newly diagnosed T2DM （T2DM group） and 35 normal control subjects （control group）. Results：Plasma visfatin and FFA levels in T2 DM group were higher than those in control group （P 〈 0. 05 ）, and there is significant higher level in T2 DM ＋ NAFLD than in control group （ P 〈 0. 01 ）. The differences among the three groups were statistically significant （ P 〈 0. 001 ）. Multi - dimension- al linear stepwise regression analysis showed waist to hip ratio（WHR） and fasting blood glucose （FBG） were independent asso- ciated factors which affected plasma Visfatin and free fatty acids level. Conclusions ： The change of plasma Visfatin and FFA level is associated closely with metabolism of glucose and lipid, that may plays a role in the pathogenesis of TEDM combined with NAFLD.