摘要
目的:观察丁苯酞对大鼠脑缺血再灌注损伤后大脑皮质细胞凋亡的影响。方法:将30只SD大鼠分成对照组(15只)和丁苯酞组(15只)。线栓法制备大鼠缺血再灌注模型,采用免疫组化法检测大脑皮层细胞凋亡数目。结果:丁苯酞组凋亡细胞数目较对照组明显减少(P<0.05)。结论:丁苯酞可减少凋亡细胞数,对大鼠脑缺血再灌注损伤具有神经保护作用。
@@@@Objective:To observe the butylphthalide on rat cerebral ischemia reperfusion injury after cerebral cortex cell apoptosis. Method:30 SD rats were divided into control group(15)and butylphthalide group(15 only). Suture methods for rat model of ischemia reperfusion,by mmunohistochemical method the number of apoptotic cells in cerebral cortex. Result:The butylphthalide group the number of apoptotic cells decreased obviously than that in control group(P<0.05). Conclusion:Butylphthalide can reduce the number of apoptotic cells,on rat cerebral ischemia reperfusion injury has a neuroprotective effect.
出处
《中国医学创新》
CAS
2013年第9期15-16,共2页
Medical Innovation of China
关键词
缺血再灌注损伤
丁苯酞
凋亡
脑
Ischemia reperfusion injury
Ding Bentai
Apoptosis
Brain
