CIP2A在慢性粒细胞白血病中的表达及意义被引量：2

Expression and Role of CIP2A in CML Cells

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摘要目的:探讨蛋白磷酸酶2A癌性抑制因子在慢性粒细胞白血病各期中的表达及意义。方法:采用免疫化学SP法测定CIP2A在对照组及CML各期中的表达。结果:CIP2A在CML-AP/BP组的表达显著高于对照组和CML-CP组(P<0.05),CML-CP组和对照组比较差异无统计学意义(P>0.05);CIP2A在CML-AP/BP未缓解组明显高于缓解组(P<0.05)。结论:CIP2A在CML-AP/BP骨髓单个核细胞中高表达且与CML发生急变及预后相关。 @@@@Objective:To investigate the expression and significance of cancerous inhibitor of protein phosphatase 2A(CIP2A)in control group and in different phases of CML.Method:The immunohistochemical SP staining was used to detect expression of CIP2A in control group and in different phases of CML.Result:Expression of CIP2A in CML-AP/BP group was significantly higher than that in control group and that in CML-CP group(P<0.05), expression of CIP2A in control group and CML-CP group had no significant difference(P>0.05).CIP2A in no remission group was significantly higher than that in complete remission group(P<0.05).Conclusion:Overexpression of CIP2A in CML bone marrow mononuclear cells plays an important role in CML blast crisis and prognosis.

作者王石松

机构地区南阳医学高等专科学校附属医院

出处《中国医学创新》 CAS 2013年第9期122-123,共2页 Medical Innovation of China

关键词蛋白磷酸酶2A癌性抑制因子慢性粒细胞白血病免疫组化 CIP2A CML Immunohistochemistry

分类号 R733.72 [医药卫生—肿瘤]

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参考文献9

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