脑白质疏松症相关危险因素分析

Research on related factors of leukoaraiosis

目的探讨LA发病的危险因素,为临床干预提供更多证据支持。方法根据磁共振检查结果,将128例患者分为无LA组和LA组,收集相关危险因素,通过单因素分析及多因素Logistic回归比较2组危险因素分布差异。结果单因素分析提示,2组年龄、吸烟史、饮酒史、高血压史、低密度脂蛋白(LDL)、血纤维蛋白原(FIB)、同型半胱氨酸(HCY)比较差异有统计学意义(P<0.05),FIB、HCY越高,LA分级程度越高(P值分别为0.006、0.000)。多因素Logistic回归表明,年龄、吸烟史、高血压、FIB与LA发病相关。结论年龄、吸烟史、高血压、高FIB血症为LA发病的危险因素。

Objective To research the related factors of leukoaraiosis（LA）, Methods Patients were divideo into two groups （non-LA group and LA group） according to MRI; statistical analysis was applied for these two sets. Results In two groups, Age, Smoking, drinklng, hypertension, low density lipoprotein （LDL）, fibrinogen （FIB）, homoeysteine （Hcy） had highly significant differences in univariate analysis（P〈0.05）. Higher FIB and hey indicated higher LA grading （P=0. 006, 0. 000）. In binary logistic, age, smoking, hypertension, FIB were related to LA. Conclusion Our study suggests that age, smoking, hypertension and FIB are related factors of LA.