盐酸法舒地尔治疗急性缺血性脑梗死临床观察

Clinical observation of hydroxyl fasudil in the treatment of acute cerebral infarction

目的观察Rho激酶抑制剂盐酸法舒地尔治疗急性脑梗死的临床疗效和安全性。方法选择我院2010-07—2011-07治疗的急性脑梗死患者96例,随机分为治疗组48例,对照组48例,对照组给予常规治疗,治疗组加用盐酸法舒地尔,观察评价2组患者神经功能缺损程度的恢复情况。结果治疗组神经功能缺损的治疗效果较对照组显著(P<0.05)。结论盐酸法舒地尔治疗急性脑梗死是安全、有效的,值得临床推广应用。

Objective To observe the clinical curative effect and safety of Rho-kinase inhibitor hydroxyl fasudil in the treatment of acule cerebral infarction. Methods A randomized study was designed to evaluate the effect of fasudil on acute cerebral infarction, with routine therapy as placebo-control. Totally 96 patients were chosen from July 2010 to July 2011 and were divided into two groups： fasudil group （48 cases） and control group （48 cases）. The recovery of neurologic impairment in the two groups was observe and compared. Results There was a significant different between the two groups about the neurologic impairment score. Conclusion The study shows that fasudil is a useful and safe drug for patients with acute cerebral infarction.