米索前列醇预防产妇产后出血的临床研究

Misoprostol for prevention of postoarturn hemorrhage in puerperas

目的观察研究米索前列醇预防产妇产后出血的临床疗效。方法将我院从2011年1月至2012年12月收治的300例顺产产妇随机均分为实验组150例（应用米索前列醇预防产妇产后出血）和对照组150例（常规缩宫素预防产后出血）。的统计并对比两组孕妇产后出血量、产后血压、止血时间以及治疗效果。结果实验组出血量[（205．3±42．7）m1]与止血时间[（8．6±3．2）h]均小于对照组[（288．7±66．3）ml，（16．3±4．1）h]，且差异有统计学意义（P〈0．05）；实验组出血量〉500m1只有1例，预防有效率达99．3％，个别例（双胎）疗效不显著，可以加10％的糖水，增加子宫肌性率，加10％葡萄糖酸钙10ml辅助疗效即可。对照组出血量〉500ml有12例，预防有效率为92．0％，组间比较差异有统计学意义（P〈0．05）。结论米索前列醇能有效降低产后出血发生率，安全高效。

Objecllve To explore the clinical efficac.y of misoprostol in the prevention of postpartum hemorrhage. Methada 30（} puerperas who had been hospitalized during the period of January 2011 to December 2012 were randomly divided into two groups. The study group （150 patients） were received misoprostol for prevention of postpartum hemorrhage, while the control group （150 patients） received routine therapy with oxytocin. Postpartum hemorrhage volume postpartum blood pressure, and time to hemostasis, and efficacy of therapies were compared between the two groups. Raattlta The amount of bleeding （205.3 ± 42.7）ml was smaller and time to hemostasis （8.6 ± 3.2）h was shorter in the study group than in the control group, with a significant statistical difference （P〈0.05）. Only one patient in the study group developed massive bleeding of 500 ml, with a effectiveness rate of prevention of 99.3%; while 12 patients occurred bleeding of 5（}0 ml, with a effectiveness rate of 92.0%; the difference between the groups was statistically significant （P〈0.05）. Cuae.luaiaaa Misoprostol can effectively reduce the incidence of postpartum hemorrhage, and it is safe and efficious.