受体活性修饰蛋白病理生理作用的研究进展

Research progress of the pathophysiological role of receptor activity modifying proteins

受体活性修饰蛋白（RAMPs）是一种具有单一跨膜功能域的蛋白，它可以与降钙素基因相关肽家族（CGRP）受体、降钙素受体（CTR）及降钙素受体样受体（CRLR）等Ⅱ型G蛋白偶联受体（GPCRs）相互作用，形成稳定的异二聚体在细胞膜上表达。不同的RAMPs可与降钙素受体样受体（CRLR）或降钙素受体（CTR）结合，形成对配体具有特异性亲和的不同受体表型，从而决定受体的生物学效应。此外，RAMPs还能与其他GPCRs相互作用，表明RAMPs在G蛋白偶联受体功能调节中具有更为广泛的作用。RAMPs对GPCRs的调节依赖于它的分子基础。RAMPs的研究为GPCRs受体功能及CGRP信号转导的研究提供了新思路。

Receptor activity modifying proteins （RAMPs） is a kind protein with transmembrane function- ality. RAMPs can interact with TypeII G protein coupled receptors （GPCRs） such as calcitonin gene-related peptide receptor （CGRPR）, calcitonin receptor （CTR） and calcitonin receptor-like receptor （CRLR）, to form a stable het- erodimer expression on the cell membrane. Different RAMPs can combine with CRLR or CTR to produce different receptor phenotypes with ligand-specific affinity and thus can decide biological effect of the receptors. In addition, RAMPs can also interact with other GPCRs, which promise broader application in function regulation of G-protein- coupled receptor of RAMPs＇. RAMPs＇ regulation of GPCRs depends on its molecular basis. Our studies of RAMPs provides a new perspective to further researches on GPCRs functionality and CGRP signal transduction.