职业人群HBV感染标记物消长情况的追踪

Follow up study on dynamic change in marks of HBV infection in occupational population

目的 了解 HBV感染的各种标记物的自然消长情况。方法 对某地职业人群 HBV感染进行随访研究。结果 1995年 HBs Ag阳性率 14.83% (35 4/ 2 387) ,1996年为 14.84% ,1997年为12 .0 3% ;抗 - HBs阳性率 1.2 2 % (2 9/ 2 387) ,年平均消长率 2 7.2 7% ,HBe Ag年阴转率 78.2 7% ,HBe Ag阳转率 15 .0 4% ,感染呈持续性与波动性 ;HBV感染的动态变化过程存在一定的群组效应 ,抗 - HBs和抗 - HBc的变化以阳转为主 ,抗 - HBs和抗 - HBc在各个年龄组均可出现。 HBV感染的模式共 10种 ,以“小三阳”型为主占 46 .0 5 % ,其次为“单阳”型 ,占 30 .79% ,再次为“大三阳”型 ,占5 .0 9% ,其余模式的比率较小。结论 人群 HBV感染标记物以阳转为主 ,阴转很少。抗 - HBc较抗- HBs稳定 ,感染 HBV时 ,抗 - HBc阳性率也较高。提示感染者可携带 HBV标记物渡过相当长的时期 。

Objective To understand the dynamic change in marks of HBV in infected persons. Methods A follow up study. Results The positive rate of HBsAg was 14.83% (354/2 387) in 1995, 14.84% (268/1 086) in 1996, 12.03% (323/2 685) in 1997. The positive rate of anti HBs was 1.22%(29/2 387), and annual negative returning rate of anti HBs was 24.92%. The positive rate of HBeAg in HBV carriers was 15.04%, and negative returning rate of HBeAg was 78.27%. There was cohort effectiveness in the process of dynamic change in HBV infection. There were ten models of HBV infection. It was the commonest model that anti HBs, anti HBc, and anti HBe emerged simultaneously, and it accounted for 46.05% of total infected persons. Only one kind of mark of HBV infection accounted for 30.79%. Conclusions After people are infected by HBV, the marks of HBV infection vary. Negative returning of marks of HBV infection seldom occures in HBV carrier. The results indicate that people who are infected by HBV could carry the marks of HBV infection for a long time, even throughout their life.