期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人脑胶质瘤的分子遗传学研究进展 被引量：1

Latest study of development on molecular genetics of human glioma
下载PDF
导出
摘要 胶质瘤是最常见的颅内肿瘤之一。近年来 ,分子遗传学领域关于胶质瘤的基因研究进展迅速 ,展示出治愈这种灾难性疾病的一线希望。本文试综述与胶质瘤相关的癌基因与抑癌基因的研究成果与进展。 Glioma is one of the most common introcranial tumors. The research on genes about glioma in the field of molecular genetics has developed quickly in recent years, and revealed some hope of curing this terrible disease. The paper reviews the outcomes and developments of scientific experiments on oncogene and tumor suppression genes about human glioma.
作者 徐培坤 李长元
机构地区 安徽医科大学第一附属医院神经外科
出处 《疾病控制杂志》 2000年第2期163-165,共3页 Chinese Journal of Disease Control and Prevention
关键词 脑胶质瘤 分子遗传学 癌基因 抑癌基因 glioma molecular genetics oncogene tumor suppression gene
分类号 R730.264 [医药卫生—肿瘤] R730.231.3 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Patt S, Cervos-Navarro J. Combined cerB gene overexpression and decreased H-ras gene expression in tumor-10 glioblastomas [J]. Acta Histochem Supple , 1992,42:131～135.
  • 2Fuller GN, Bigner SH. Amlfied cellular oncogenes in neoplasms of the human central nervous system [J]. Mutant Research , 1992,276:299.
  • 3Schlegel J, Merdes A, Stumm G, et al. Amplification of the epidemal-growth-factor-receptor gene correlates with different growth behavior in human glioblastoma [J]. Int J Cancer, 1994,56:72～78.
  • 4Nitta T, Sato K. Specific inhibiton of c-sis protein synthesis and cell proliferation with antisense oligodeoxynucleotides in human glioma cells [J]. Neurosurgery , 1994,34..309～313.
  • 5Holt JT, Redner RL, Neinhuis AW, et al. An oligomer complementaxy to c-myc-mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation [J]. Mol cell Biol , 1988,8:963～965.
  • 6He J, Olson JJ, Jamas CD. Lack of P161NK4 or retinoblastoms protein (PR6) or amplification-associated overexpression of CDK4 is observed in distinct subsets of malignant glial tumors and cell lines [J]. Cancer Res , 1995,55:4833～4840.
  • 7Hartwell LH, Kastan MB. Cell cycle control and cancer [J]. Science , 1994,266: 1821～1947.
  • 8Nishikawa R, Furnari FB, Lin H, et al. Loss of P16INK4 expression is frequent in high grade gliomas [J]. Cancer Res, 1995,55:1941～1947.
  • 9姚雪峰,赵洪洋,朱贤立.脑胶质细胞瘤CDK4基因的表达及其意义[J].中国临床神经外科杂志,1999,4(2):31-32. 被引量：1
  • 10Tabuchi K, Fukuyama K, Mineta T, et al. Altered structure and expression of the P53 gene in human neuroepitheli tumors [J]. Neurol Med Chir Tokyo , 1992,32: 725～731.

共引文献6

同被引文献21

  • 1Kayaselcuk F,Zorludemir S,Gumurdulu D,et al.PCNA and Ki-67 in central nervous system tumors:correclation with the histological and grade.J Neurooncol,2002;57:115～121
  • 2Reavey-Cantwell JF,Haroun RI,Zahurak M,et al.The prognostic value of tumor markers in patients with glioblastoma multiforme:analysis of 32 patients and review of the literature.J Neurooncol,2001;55:195～204
  • 3Huang FH,Kanno HS,Yamamotol I,et al.Correlation of clinical features and telomerase activity in human gliomas.J Neurooncol,1999;43:137～142
  • 4Falchetti ML,Pallini R,Larocca LM,et al.Telomerase expression in intracranial tumours:prognostic potential for malignant gliomas and meningiomas.J Clin Pathol,1999;52:234～236
  • 5Iny V,Edwards V,Halliday W,et al."Ployphenotypic" tumors in the central nervous system:problems in nosology and classification.Pedictr Pathol Lab Med,1997;17(3):369～389
  • 6Maity A,Pore N,Lee J,et al.Epidermal growth factor recepor transcriptionally upregulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway in-kinase and distinct from that volving phoshatidylinositol3*induced by hypoxial.Cancer Res,2000;60:5879～5886
  • 7Jin W,Xu X,Yang T,et al.p53 mutation,EGGR gene amplification and loss of heterozygosity on chromosome 10,17p in human gliomas.Chin Med J(Engl),2000;113(7):662～666
  • 8Schiebe M,Ohneseit P,Hoffmann W,et al.Loss of heterozygosity at 1 1p15 and p53 alterations in malignant gliomas.J Cancer Res Clin Oncol,2001;127(5):325～328
  • 9Kato H,Kato S,Kumabe T,et al.Functional evaluation of p53 and PTEN gene mutations in gliomas.Clin Cancer Res,2000;6(10):3937～3943
  • 10Nieder C,Petersen S,Petersen C,et al.The challenge of p53as prognostic and predictive factor in gliomas.Cancer Treat Rev,2000;26(1):67～73

引证文献1

二级引证文献1

疾病控制杂志
2000年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部