尼麦角林对脑卒中患者的血清P物质及吞咽功能的影响

Effect of nicergoline on serum substance P and swallowing function in ischemic stroke patients

目的观察尼麦角林对脑卒中患者血清P物质及吞咽功能的影响。方法选择伴有吞咽功能障碍的脑梗死患者46例,随机分为尼麦角林组23例(15mg/d)和对照组23例,通过电视X线透视吞咽功能检查基线及治疗4周后的吞咽功能,采用放射免疫法检测治疗前后血清P物质水平。结果尼麦角林组治疗4周后吞咽功能较治疗前明显改善[(5.13±1.71)分vs(6.70±1.55)分,P<0.01],血清P物质水平显著升高[(101.6±53.2)ng/L vs(179.3±49.2)ng/L,P<0.01];对照组治疗前后吞咽功能和血清P物质水平差异无统计学意义(P>0.05)。吞咽功能改善与血清P物质升高呈正相关(R2=0.746,P<0.01)。结论尼麦角林可能通过上调血清中的P物质而改善脑卒中患者的吞咽功能。

Obieetive To study the effect of nicergoline on serum substance P and swallowing function in ischemie stroke patients. Methods Forty-six ischemic stroke patients with dysphagia were randomly divided into nicergoline treatment group（n=23） and control group（n=23）. Patients in nicergoline treatment group were given 15 mg nicergoline daily. Their swallowing function was detected before and after 4 weeks of nicergoline treatment by television X-ray examination and their serum substance P level was measured by ELISA. Results The swallowing function score of the patients was signicantly higher after treatment than before treatment（5.13±1.71 v,s 6.70± 1.55 ,P〈0.01） and the serum substance P level was significantly higher in nicergoline treatment group than in control group（101.6±53.2 ng/L vs 179.3±49.2 ng/L,P〈0.01）. Improvement of swallowing function was positively related with the serum substance P level （R2 = 0. 746, P〈0.01）. Conclusion Nicergoline can improve the swallowing function of iscbemic stroke patients by upregulating their serum substance P level.