期刊文献+

诊断阿尔茨海默病新药Amyvid 被引量:2

Amyvid,a new agent for the diagnosis of Alzheimer's disease
原文传递
导出
摘要 Amyvid是首个脑部淀粉样斑块显影剂,于2012年4月6日通过美国食品药品管理局(FDA)批准用于诊断阿尔茨海默病(Alzheimer's disease,AD)。文中综述了阿尔茨海默病的现状以及Amyvid的理化性质、作用机制、药动学、药效学、不良反应、临床评价等内容。 Amyvid is a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging of the brain to estimate the density of β-amyloid neuritic plaque in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) and other causes of cognitive decline. It was approved by U. S. Food and Drug Administration (FDA) on April 6, 2012. We reviewed the present situation of AD research, and the physical and chemical properties, mechanism of action, pharmacokinetics, pharmacodynamics, adverse reactions and clinical evaluation of Amyvid in this paper.
出处 《中国新药杂志》 CAS CSCD 北大核心 2013年第7期739-742,共4页 Chinese Journal of New Drugs
关键词 阿尔茨海默病 Amyvid 氟倍他帕F 18 脑部淀粉样斑块显影剂 Alzheimer's disease Amyvid florbetapir F 18 cerebral amyloid plaques developer
  • 相关文献

参考文献19

  • 1ALZHEIMER A, STELZMANN RA, SCHNITZLEIN HN, et al. An English translation of Alzheimer's 1907 paper, " Uber eine eigenartige Erkankung der Hirnrinde. " [J]. Clin Anat, 1995, 8 (6) : 429 -431.
  • 2Alzheimer's association. 2012 Alzheimer's disease facts and figures[J]. AlzheimersDement, 2012, 8(2) :131-168.
  • 3OSCAR L, LOPEZ MD. The growing burden of Alzheimer's disease[J]. Am J Manag Care, 2011, 17: S339- S345.
  • 4PICCINI A. CSF biomarkers[J]. Open Nucl Med J, 2010, 2: 25 - 30.
  • 5LIM A, TSUANG D, KUKULL W, et al. Clinico-neuropathological correlation of Alzheimer's disease in a communitybased case series[ J ]. J Am Geriatr Soc, 1999, 47 (5) : 564 - 569.
  • 6PETROVITCH H, WHITE LR, ROSS GW, et al. Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study [ J ]. Neurology, 2001, 57 (2) : 226 - 234.
  • 7HYMAN BT, PHELPS CH, BEACH TG, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease[ J]. Alzheimers Dement, 2012, 8(1):1-13.
  • 8MCKHANN GM, KNOPMAN DS, CHERTKOW H, et al. The diagnosis of dementia due to Alzheimer's disease: recommenda- tions from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [ J ]. Alzheimers Dement, 2011, 7(3) :263 -269.
  • 9SPERLING RA, AISEN PS, BECKETT LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommenda- tions from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [ J ]. Alzheimers Dement, 2011, 7(3) : 280 -292.
  • 10PUBCHEM. Florbetapir F18 [ EB/OL ]. http ://pubchem. ncbi. nlm. nih. gov/summary/summary, cgi? cid = 24822371.

同被引文献30

引证文献2

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部